Bromo-PEG1-CH2-Boc

Modify Date: 2024-01-08 21:31:21

Bromo-PEG1-CH2-Boc Structure
Bromo-PEG1-CH2-Boc structure
Common Name Bromo-PEG1-CH2-Boc
CAS Number 157759-50-7 Molecular Weight 239.107
Density 1.3±0.1 g/cm3 Boiling Point 268.1±15.0 °C at 760 mmHg
Molecular Formula C8H15BrO3 Melting Point N/A
MSDS N/A Flash Point 115.9±20.4 °C

 Use of Bromo-PEG1-CH2-Boc


Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bromo-PEG1-CH2CO2tBu
Synonym More Synonyms

 Bromo-PEG1-CH2-Boc Biological Activity

Description Bromo-PEG1-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 268.1±15.0 °C at 760 mmHg
Molecular Formula C8H15BrO3
Molecular Weight 239.107
Flash Point 115.9±20.4 °C
Exact Mass 238.020447
LogP 2.43
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.460

 Synonyms

Acetic acid, 2-(2-bromoethoxy)-, 1,1-dimethylethyl ester
2-Methyl-2-propanyl (2-bromoethoxy)acetate
MFCD28122952