Bromo-PEG2-CH2-Boc

Modify Date: 2024-01-27 11:41:30

Bromo-PEG2-CH2-Boc Structure
Bromo-PEG2-CH2-Boc structure
Common Name Bromo-PEG2-CH2-Boc
CAS Number 1807518-63-3 Molecular Weight 283.159
Density 1.3±0.1 g/cm3 Boiling Point 316.4±22.0 °C at 760 mmHg
Molecular Formula C10H19BrO4 Melting Point N/A
MSDS N/A Flash Point 145.2±22.3 °C

 Use of Bromo-PEG2-CH2-Boc


Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-Methyl-2-propanyl [2-(2-bromoethoxy)ethoxy]acetate
Synonym More Synonyms

 Bromo-PEG2-CH2-Boc Biological Activity

Description Bromo-PEG2-CH2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 316.4±22.0 °C at 760 mmHg
Molecular Formula C10H19BrO4
Molecular Weight 283.159
Flash Point 145.2±22.3 °C
Exact Mass 282.046661
LogP 2.16
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.462

 Synonyms

2-Methyl-2-propanyl [2-(2-bromoethoxy)ethoxy]acetate
Acetic acid, 2-[2-(2-bromoethoxy)ethoxy]-, 1,1-dimethylethyl ester
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