SR 140333

Modify Date: 2025-08-25 18:03:28

SR 140333 Structure
SR 140333 structure
Common Name SR 140333
CAS Number 153050-21-6 Molecular Weight 656.12
Density N/A Boiling Point N/A
Molecular Formula C37H45Cl3N2O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SR 140333


Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1].

 Names

Name 22O6ξ63E0
Synonym More Synonyms

 SR 140333 Biological Activity

Description Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1].
Related Catalog
Target

NK1

References

[1]. Emonds-Alt X, et al. In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. Eur J Pharmacol. 1993 Dec 21;250(3):403-13.

 Chemical & Physical Properties

Molecular Formula C37H45Cl3N2O2
Molecular Weight 656.12
Exact Mass 654.254639
InChIKey NQHFSECYQAQZBN-UHFFFAOYSA-M
SMILES CC(C)Oc1cccc(CC(=O)N2CCCC(CC[N+]34CCC(c5ccccc5)(CC3)CC4)(c3ccc(Cl)c(Cl)c3)C2)c1.[Cl-]

 Synonyms

1-Azoniabicyclo[2.2.2]octane, 1-[2-[(3S)-3-(3,4-dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-, chloride (1:1)
22O6ξ63E0
1-(2-{(3S)-3-(3,4-Dichlorophenyl)-1-[(3-isopropoxyphenyl)acetyl]-3-piperidinyl}ethyl)-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride
1-{2-[(3S)-3-(3,4-dichlorophenyl)-1-{[3-(propan-2-yloxy)phenyl]acetyl}piperidin-3-yl]ethyl}-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride
NOLPITANTIUM CHLORIDE
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