SR-1277
Modify Date: 2024-04-05 18:17:57
SR-1277 structure
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Common Name | SR-1277 | ||
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| CAS Number | 1446715-47-4 | Molecular Weight | 477.50 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H19N9O3S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SR-1277SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1]. |
| Name | SR-1277 |
|---|
| Description | SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
CKIδ:49 nM (IC50) CKIϵ:260 nM (IC50) |
| In Vitro | SR-1277 exhibits antiproliferative effects in A375 cells, with an EC50 of 22 nM[1]. |
| In Vivo | SR-1277 (1 mg/kg; i.v.) exhibits Cmax (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM•h), T1/2 (1.42 h) and brain penetration (24%) in mice[1]. |
| References |
| Molecular Formula | C21H19N9O3S |
|---|---|
| Molecular Weight | 477.50 |