1446715-47-4

1446715-47-4 structure

Name: SR-1277
Chemical Name: SR-1277
CAS Number: 1446715-47-4
Molecular Formula: C₂₁H₁₉N₉O₃S
Molecular Weight: 477.50
Catalog: Signaling Pathways Cell Cycle/DNA Damage Casein Kinase
Create Date: 2021-12-19 12:58:58
Modify Date: 2024-04-05 18:17:57
SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1].

Name	SR-1277

Description	SR-1277 is a potent, selective and ATP competitive CK1δ/ε inhibitor, with IC50s of 49 nM and 260 nM, respectively. SR-1277 also inhibits FLT3, CDK4/cyclin D1, CDK6/cyclin D3 and CDK9/cyclin K, with IC50s of 305 nM, 1340 nM, 311 nM and 109 nM, respectively. SR-1277 can be used for the research of cancer[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Casein Kinase Signaling Pathways >> Stem Cell/Wnt >> Casein Kinase
Target	CKIδ:49 nM (IC50) CKIϵ:260 nM (IC50)
In Vitro	SR-1277 exhibits antiproliferative effects in A375 cells, with an EC50 of 22 nM[1].
In Vivo	SR-1277 (1 mg/kg; i.v.) exhibits Cmax (1.2 μM), Cl (2.8 ml/min/kg), AUC(1.26 μM•h), T1/2 (1.42 h) and brain penetration (24%) in mice[1].
References	[1]. Bibian M, et, al. Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties. Bioorg Med Chem Lett. 2013 Aug 1;23(15):4374-80.

Molecular Formula	C₂₁H₁₉N₉O₃S
Molecular Weight	477.50