SR 140333

Names

[ Name ]:
SR 140333

[Synonym ]:
1-Azoniabicyclo[2.2.2]octane, 1-[2-[(3S)-3-(3,4-dichlorophenyl)-1-[2-[3-(1-methylethoxy)phenyl]acetyl]-3-piperidinyl]ethyl]-4-phenyl-, chloride (1:1)
22O6ξ63E0
1-(2-{(3S)-3-(3,4-Dichlorophenyl)-1-[(3-isopropoxyphenyl)acetyl]-3-piperidinyl}ethyl)-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride
1-{2-[(3S)-3-(3,4-dichlorophenyl)-1-{[3-(propan-2-yloxy)phenyl]acetyl}piperidin-3-yl]ethyl}-4-phenyl-1-azoniabicyclo[2.2.2]octane chloride
NOLPITANTIUM CHLORIDE

Biological Activity

[Description]:

Nolpitantium (SR140333) is a potent, selective, competitive, non-peptide tachykinin NK1 receptor antagonist. Nolpitantium blocks the activation of rat thalamic neurons after nociceptive stimulation[1].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor

[Target]

NK1

[References]

[1]. Emonds-Alt X, et al. In vitro and in vivo biological activities of SR140333, a novel potent non-peptide tachykinin NK1 receptor antagonist. Eur J Pharmacol. 1993 Dec 21;250(3):403-13.

Chemical & Physical Properties

[ Molecular Formula ]:
C₃₇H₄₅Cl₃N₂O₂

[ Molecular Weight ]:
656.12

[ Exact Mass ]:
654.254639

Related Compounds

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