Vorinostat(SAHA)

Modify Date: 2024-01-02 18:08:37

Vorinostat(SAHA) structure	Common Name	Vorinostat(SAHA)
	CAS Number	149647-78-9	Molecular Weight	264.320
	Density	1.2±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₄H₂₀N₂O₃	Melting Point	161-162°C
	MSDS	Chinese USA	Flash Point	N/A
	Symbol	GHS08	Signal Word	Danger

Use of Vorinostat(SAHA)

Vorinostat is a potent and orally available inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV ), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively.

Name	vorinostat
Synonym	More Synonyms

Description	Vorinostat is a potent and orally available inhibitor of HDAC1, HDAC2 and HDAC3 (Class I), HDAC7 (Class II) and HDAC11 (Class IV ), with ID50 values of 10 nM and 20 nM for HDAC1 and HDAC3, respectively.
Related Catalog	Signaling Pathways >> Autophagy >> Autophagy Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC Signaling Pathways >> Autophagy >> Mitophagy Research Areas >> Cancer
Target	HDAC1:10 nM (ID50) HDAC3:20 nM (ID50) HDAC2 HDAC7 HDAC11 Mitophagy Autophagy
In Vitro	Vorinostat efficiently suppresses MES-SA cell growth at a low dosage (3 μM) already after 24 hours treatment. HDACs class I (HDAC2 and 3) as well as class II (HDAC7) are preferentially affected by this treatment. Vorinostat significantly increases p21WAF1 expression and apoptosis in MES-SA cells[1]. Vorinostat inhibits SK-N-SH and SK-N-Be(2)C with the IC25 values of 1 µM and 0.5 µM, respectively[2].
In Vivo	Vorinostat (50 mg/kg/day) reduces tumor growth by more than 50% in nude mice injected with 5×106 MES-SA cells[1].
Cell Assay	Cell lysates are prepared by using RIPA buffer (25 mM Tris-HCl pH 7.6, 150 mM NaCl, 1% NP-40, 1% sodium deoxycholate, 0.1% SDS), and the protein concentration is determined by Bio-Rad DC Protein Assay. Protein lysates are separated by SDS-PAGE and transferred to nitrocellulose membrane. Following antibodies and dilutions are used: rabbit anti HDAC1 (1 μg/mL); rabbit anti HDAC2 (1 μg/mL); rabbit anti HDAC3 (9 μg/mL); rabbit anti HDAC7 (3 μg/mL); mouse anti p21WAF1 (0.5 μg/mL). As secondary antibodies, the rabbit anti-mouse and swine anti-rabbit HRP-coupled antibodies at a final concentration of 1 μg/mL. An overnight incubation at 4°C is used for all primary antibodies, followed by washing and 2-hours incubation at RT with secondary antibodies. Specific protein bands are visualized by enhanced chemiluminescence assay. To demonstrate equal loading of protein samples all western blots are probed for β-tubulin.
Animal Admin	Twelve weeks old male mice (n=14) are anesthetized with Isofluran and 5×106 MES-SA cells are injected subcutaneously into the right flank of the animal. Mice from a control group receives placebo containing 300 μL of empty HOP-β-CD (2-hydroxypropyl-β-cyclodextrin) vesicles. Another group of mice receives vorinostat dissolved in HOP-β-CD at a concentration of 50 mg/kg/day. Both, empty vesicles and vorinostat are administered intraperitoneally, starting on the day 4 after the injection of MES-SA tumor cells. Mice body weight and tumor size (w2 × l × 0.52; measured by caliper) are estimated twice a week. All mice are treated for 21 days and afterwards sacrificed by cervical dislocation. Each tumor is isolated as a whole and different tumor parameters are determined. Finally, tumor slices are cryo preserved and formalin fixed (4%) for further analyses.
References	[1]. Hrzenjak A et al. Histone deacetylase inhibitor vorinostat suppresses the growth of uterine sarcomas in vitro and in vivo. Mol Cancer. 2010 Mar 4;9:49. [2]. Lautz TB, et al. The effect of vorinostat on the development of resistance to Doxorubicin in neuroblastoma.PLoS One. 2012;7(7):e40816. [3]. Richon VM, et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3003-7. [4]. Xu WS, et al. Histone deacetylase inhibitors: molecular mechanisms of action. Oncogene. 2007 Aug 13;26(37):5541-52. [5]. Pérez-Cañamás A, et al. Sphingomyelin-induced inhibition of the plasma membrane calcium ATPase causes neurodegeneration in type A Niemann-Pick disease. Mol Psychiatry. 2017 May;22(5):711-723. [6]. Wang J, et al. Snail determines the therapeutic response to mTOR kinase inhibitors by transcriptional repression of 4E-BP1. Nat Commun. 2017 Dec 20;8(1):2207.

Density	1.2±0.1 g/cm3
Melting Point	161-162°C
Molecular Formula	C₁₄H₂₀N₂O₃
Molecular Weight	264.320
Exact Mass	264.147400
PSA	78.43000
LogP	0.86
Index of Refraction	1.567
Storage condition	-20°C Freezer

Vorinostat(SAHA) MSDS(Chinese)

Symbol	GHS08
Signal Word	Danger
Hazard Statements	H341-H360
Precautionary Statements	P201-P281-P308 + P313
Hazard Codes	T,Xn
Risk Phrases	R61:May cause harm to the unborn child. R20/21:Harmful by inhalation and in contact with skin . R36:Irritating to the eyes. R36/37/38:Irritating to eyes, respiratory system and skin . R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
Safety Phrases	S53-S45-S24/25-S22
RIDADR	UN 2265 3/PG 3
WGK Germany	3
RTECS	SJ7453000
HS Code	29349990

Precursor 6
CAS#:149648-52-2 Suberanilic Acid CAS#:162853-41-0 METHYL 8-OXO-8-... CAS#:505-48-6 Octanedioic acid CAS#:149647-86-9 8-(hydroxyamino...
CAS#:3946-32-5 SUBERIC ACID MO... CAS#:10521-06-9 Suberic anhydride
DownStream 0

HS Code	2924299090
Summary	2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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SAHA

Suberoylanilidehydroxamic Acid

N-Hydroxy-N'-phenyloctanediamide

M344

Vorinostat/SAHA

Vorinostat

suberoylanilide hydroxamic acid

suberanilohydroxamic acid

Zolinza

Octanediamide, N-hydroxy-N-phenyl-

BioBioPha
China
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Purity: 98.0%
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China
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China
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Henan Tianfu Chemical Co., Ltd.
China
Product Name: SAHA (vorinostate)
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Purity: 99.0%
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