Vorinostat(SAHA)
Vorinostat(SAHA) structure
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Common Name | Vorinostat(SAHA) | ||
|---|---|---|---|---|
| CAS Number | 149647-78-9 | Molecular Weight | 264.320 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C14H20N2O3 | Melting Point | 161-162°C | |
| MSDS | Chinese USA | Flash Point | N/A | |
| Symbol |
GHS08 |
Signal Word | Danger | |
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Epigenetic reprogramming of the type III interferon response potentiates antiviral activity and suppresses tumor growth.
PLoS Biol. 12(1) , e1001758, (2014) Type III interferon (IFN-λ) exhibits potent antiviral activity similar to IFN-α/β, but in contrast to the ubiquitous expression of the IFN-α/β receptor, the IFN-λ receptor is restricted to cells of epithelial origin. Despite the importance of IFN-λ in tissue-... |
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Targeting the invasive phenotype of cisplatin-resistant non-small cell lung cancer cells by a novel histone deacetylase inhibitor.
Biochem. Pharmacol. 94(2) , 79-90, (2015) Non-Small Cell Lung Cancer (NSCLC) remains an aggressive and fatal disease with low responsiveness to chemotherapy, frequent drug resistance development and metastatic behavior. Platinum-based therapy is the standard of care for NSCLC with limited benefits. S... |
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Rational combination treatment with histone deacetylase inhibitors and immunomodulatory drugs in multiple myeloma.
Blood Cancer J. 5 , e312, (2015) Immunomodulatory drugs (IMiDs) thalidomide, lenalidomide (Len) and pomalidomide trigger anti-tumor activities in multiple myeloma (MM) by targetting cereblon and thereby impacting IZF1/3, c-Myc and IRF4. Histone deacetylase inhibitors (HDACi) also downregulat... |
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4-(1-Ethyl-4-anisyl-imidazol-5-yl)-N-hydroxycinnamide - A new pleiotropic HDAC inhibitor targeting cancer cell signalling and cytoskeletal organisation.
Exp. Cell Res. 336 , 263-75, (2015) Histone deacetylases (HDAC) which play a crucial role in cancer cell proliferation are promising drug targets. However, HDAC inhibitors (HDACi) modelled on natural hydroxamic acids such as trichostatin A frequently lead to resistance or even an increased agre... |
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Epigenetic modification and preliminary investigation of the mechanism of the immune evasion of HL-60 cells.
Mol. Med. Report. 12 , 1059-65, (2015) The aim of the present study was to explore the effect of epigenetic modification of class II transactivator (CIITA) methylation on histocompatibility complex (MHC) class II expression and the immune evasion of leukemia HL-60 cells. HL-60 cells were treated w... |
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Prenatal alcohol exposure causes the over-expression of DHAND and EHAND by increasing histone H3K14 acetylation in C57 BL/6 mice.
Toxicol. Lett. 228(3) , 140-6, (2014) Prenatal alcohol exposure leads to congenital heart abnormal development, its mechanisms are still unknown. Recent reports have associated alcohol exposure with histone H3 acetylation. In the present study, we have performed the experiments to test the hypoth... |
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Epigenetic regulation of microRNA expression in renal cell carcinoma
Biochem. Biophys. Res. Commun. 436(1) , 79-84, (2013) • microRNAs are silenced by histone acetylation. • 5-Aza-2′dC and SAHA induce microRNA re-expression. • 5-Aza-2′dC and SAHA are most efficient in combination. |
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Neuronal developmental gene and miRNA signatures induced by histone deacetylase inhibitors in human embryonic stem cells.
Cell Death Dis. 6 , e1756, (2015) Human embryonic stem cells (hESCs) may be applied to develop human-relevant sensitive in vitro test systems for monitoring developmental toxicants. The aim of this study was to identify potential developmental toxicity mechanisms of the histone deacetylase in... |
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FACT Proteins, SUPT16H and SSRP1, Are Transcriptional Suppressors of HIV-1 and HTLV-1 That Facilitate Viral Latency.
J. Biol. Chem. 290 , 27297-310, (2015) Our functional genomic RNAi screens have identified the protein components of the FACT (facilitates chromatin transcription) complex, SUPT16H and SSRP1, as top host factors that negatively regulate HIV-1 replication. FACT interacts specifically with histones ... |
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Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1.
Virology 485 , 340-54, (2015) Vesicular stomatitis virus (VSV) is an effective oncolytic virus against most human pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to oncolytic VSV-ΔM51 infection. To better understand the mechanism of r... |