ω-Agatoxin IVa trifluoroacetate salt
ω-Agatoxin IVa trifluoroacetate salt structure
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Common Name | ω-Agatoxin IVa trifluoroacetate salt | ||
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| CAS Number | 145017-83-0 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C217H360N68O60S10 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of ω-Agatoxin IVa trifluoroacetate saltω-Agatoxin IVA is a potent, selective P/Q type Ca2+ channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels[1][2]. |
| Name | ω-Agatoxin IVA |
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| Description | ω-Agatoxin IVA is a potent, selective P/Q type Ca2+ channel blocker with IC50s of 2 nM and 90 nM for P-type and Q-type Ca2+ channels, respectively. ω-Agatoxin IVA (IC50, 30-225 nM) inhibits glutamate exocytosis and calcium influx elicited by high potassium. ω-Agatoxin IVA also blocks the high potassium-induced release of serotonin and norepinephrine. ω-Agatoxin IVA has no effect on L-type or N-type calcium channels[1][2]. |
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| Related Catalog | |
| Target |
IC50: 2 nM (P-type Ca2+ channels), 90 nM (Q-type Ca2+ channels)[1] |
| References |
| Molecular Formula | C217H360N68O60S10 |
|---|---|
| InChIKey | NVVFOMZVLALQKT-UHFFFAOYSA-N |
| SMILES | CCC(C)C1NC(=O)C(NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(N)CCCCN)CSSCC2NC(=O)C3CSSCC(C(=O)NC(CCCCN)C(=O)N4CCCC4C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)C(C)CC)NC(=O)C(CCC(=O)O)NC(=O)C4CSSCC(NC(=O)C(C(C)CC)NC(=O)C(CSSCC(NC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(Cc5ccc(O)cc5)NC(=O)C(CC(=O)O)NC(=O)C(CCCCN)NC(=O)C(C)NC1=O)C(=O)NC(CCCCN)C(=O)NC(Cc1c[nH]c5ccccc15)C(=O)NCC(=O)NCC(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)N3)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CCCNC(=N)N)NC2=O)C(=O)NC(CO)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NCC(=O)NC(C(C)O)C(=O)NC(CC(N)=O)C(=O)N4 |
| RIDADR | NONH for all modes of transport |
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P-type calcium channels blocked by the spider toxin omega-Aga-IVA.
Nature 355 , 827-829, (1992) Voltage-dependent calcium channels mediate calcium entry into neurons, which is crucial for many processes in the brain including synaptic transmission, dendritic spiking, gene expression and cell dea... |
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P-type calcium channels in rat central and peripheral neurons.
Neuron 9 , 85-95, (1992) The peptide toxin omega-Aga-IVA blocked P-type Ca2+ channel current in rat Purkinje neurons (KD approximately 2 nM) but had no effect on identified T-type, L-type, or N-type currents in a variety of c... |
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Calcium channels coupled to glutamate release identified by omega-Aga-IVA.
Science 258 , 310-313, (1992) Presynaptic calcium channels are crucial elements of neuronal excitation-secretion coupling. In mammalian brain, they have been difficult to characterize because most presynaptic terminals are too sma... |