ω-Agatoxin TK
ω-Agatoxin TK structure
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Common Name | ω-Agatoxin TK | ||
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| CAS Number | 158484-42-5 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C215H337N65O70S10 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of ω-Agatoxin TKω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca2+ channel blocker. ω-Agatoxin TK inhibits the high K+ depolarisation-induced rise in internal Ca2+ in cerebral isolated nerve endings with an IC50 of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels[1][2][3]. |
| Name | ω-Agatoxin TK |
|---|
| Description | ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca2+ channel blocker. ω-Agatoxin TK inhibits the high K+ depolarisation-induced rise in internal Ca2+ in cerebral isolated nerve endings with an IC50 of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels[1][2][3]. |
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| Related Catalog | |
| Target |
P/Q type Ca2+ channel |
| References |
| Molecular Formula | C215H337N65O70S10 |
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| RIDADR | NONH for all modes of transport |
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Controlling transgene expression in subcutaneous implants using a skin lotion containing the apple metabolite phloretin.
Proc. Natl. Acad. Sci. U. S. A. 106 , 10638-43, (2009) Adjustable control of therapeutic transgenes in engineered cell implants after transdermal and topical delivery of nontoxic trigger molecules would increase convenience, patient compliance, and elimin... |
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Calcium in sympathetic boutons of rat superior cervical ganglion during facilitation, augmentation and potentiation.
J. Auton. Nerv. Syst. 73 , 26-37, (1998) The sympathetic preganglionic nerve terminals of the rat superior cervical ganglion were loaded with the calcium indicator oregon green 488 BAPTA-1 to measure the change in calcium concentration in th... |
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Serotonergic inhibition of the T-type and high voltage-activated Ca2+ currents in the primary sensory neurons of Xenopus larvae.
J. Neurosci. 17 , 6839-6849, (1997) The primary sensory Rohon-Beard (R-B) neurons of Xenopus larvae are highly analogous to the C fibers of the mammalian pain pathway. We explored the actions of 5-HT by studying the modulation of Ca2+ c... |