ω-Agatoxin TK
ω-Agatoxin TK structure
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Common Name | ω-Agatoxin TK | ||
|---|---|---|---|---|
| CAS Number | 158484-42-5 | Molecular Weight | N/A | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C215H337N65O70S10 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of ω-Agatoxin TKω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca2+ channel blocker. ω-Agatoxin TK inhibits the high K+ depolarisation-induced rise in internal Ca2+ in cerebral isolated nerve endings with an IC50 of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels[1][2][3]. |
| Name | ω-Agatoxin TK |
|---|
| Description | ω-Agatoxin TK, a peptidyl toxin of the venom of Agelenopsis aperta, is a potent and selective P/Q type Ca2+ channel blocker. ω-Agatoxin TK inhibits the high K+ depolarisation-induced rise in internal Ca2+ in cerebral isolated nerve endings with an IC50 of of 60 nM. ω-Agatoxin TK has no effect on L-type, N-type, or T-type calcium channels[1][2][3]. |
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| Related Catalog | |
| Target |
P/Q type Ca2+ channel |
| References |
| Molecular Formula | C215H337N65O70S10 |
|---|---|
| InChIKey | MBXCGHHUBOKUGG-UHFFFAOYSA-N |
| SMILES | CCC(C)C1NC(=O)C(CCSC)NC(=O)C(CO)NC(=O)C2CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(C(C)O)NC(=O)CNC1=O)C(=O)NC(CCC(=O)O)C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(CO)C(=O)NC(Cc1ccccc1)C(=O)NC(C)C(=O)O)C(C)CC)C(C)O)CSSCC1NC(=O)C(CCCCN)NC(=O)C(C(C)O)NC(=O)CNC(=O)CNC(=O)C(Cc3c[nH]c4ccccc34)NC(=O)C(C(C)O)NC(=O)C3CSSCC(NC(=O)C4CCCN4C(=O)C(CCCNC(=N)N)NC(=O)CNC(=O)C(CCCNC(=N)N)NC(=O)C(CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CC(=O)O)NC(=O)C(N)CCC(=O)O)C(=O)NC(C(C)CC)C(=O)NC(C)C(=O)NC(CCC(=O)O)C(=O)NC(CC(=O)O)C(=O)NC(Cc4ccc(O)cc4)C(=O)NCC(=O)NC(CCCCN)C(=O)N3)NC1=O)C(=O)NC(CCCNC(=N)N)C(=O)N2 |
| RIDADR | NONH for all modes of transport |
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Calcium in sympathetic boutons of rat superior cervical ganglion during facilitation, augmentation and potentiation.
J. Auton. Nerv. Syst. 73 , 26-37, (1998) The sympathetic preganglionic nerve terminals of the rat superior cervical ganglion were loaded with the calcium indicator oregon green 488 BAPTA-1 to measure the change in calcium concentration in th... |
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Serotonergic inhibition of the T-type and high voltage-activated Ca2+ currents in the primary sensory neurons of Xenopus larvae.
J. Neurosci. 17 , 6839-6849, (1997) The primary sensory Rohon-Beard (R-B) neurons of Xenopus larvae are highly analogous to the C fibers of the mammalian pain pathway. We explored the actions of 5-HT by studying the modulation of Ca2+ c... |