Neuropeptide S (human) trifluoroacetate salt
Modify Date: 2024-01-02 12:31:29
Neuropeptide S (human) trifluoroacetate salt structure
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Common Name | Neuropeptide S (human) trifluoroacetate salt | ||
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| CAS Number | 412938-67-1 | Molecular Weight | 2187.48000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C93H155N31O28S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Neuropeptide S (human) trifluoroacetate saltNeuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice. |
| Name | neuropeptide s (human) |
|---|---|
| Synonym | More Synonyms |
| Description | Neuropeptide S human is a potent endogenous neuropeptide S receptor agonist (EC50= 9.4 nM). Neuropeptide S human increases locomotor activity and wakefulness in mice. Neuropeptide S human also reduces anxiety-like behavior in mice. |
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| Related Catalog | |
| Target |
EC50: 9.4 nM (neuropeptide S receptor)[1] |
| In Vitro | Neuropeptide S (human)(4 pM to 1.7 nM; 48 hours)retains full agonist activity with an EC50 of 6.7 ± 2.4 nM, the binding of [125I] Y10-hNPS to CHO cells stably expressing hNPSR is saturable with high affinity (Kd = 0.33 ± 0.12 nM)[1]. Neuropeptide S (human)(1 pM - 3 μM; 48 hours) are used to compete with 0.15 nM [125I] Y10-NPS, [125I] Y10-NPS is displaceable by increasing concentrations of human NPS (IC50 = 0.42 ± 0.12 nM) [1]. |
| In Vivo | Neuropeptide S (human) (intracerebroventricular (i.c.v.) injection; 0.1 nMor 1 nM; 60 mins) causes a significant increase in locomotor activity, the total distance traveled, percentage of time moving, number of rearing events, and center entries are also significantly increased in mice. |
| Molecular Formula | C93H155N31O28S |
|---|---|
| Molecular Weight | 2187.48000 |
| Exact Mass | 2186.14000 |
| PSA | 1030.71000 |
| SFRNGVGTGMKKTSFQRAKS |
| H-SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER-OH |
| Neuropeptide S,NPS,human |
| SER-PHE-ARG-ASN-GLY-VAL-GLY-THR-GLY-MET-LYS-LYS-THR-SER-PHE-GLN-ARG-ALA-LYS-SER |
| REF DUPL: H-Ser-Phe-Arg-Asn-Gly-Val-Gly-Ser-Gly-Ala-Lys-Lys-Thr-Ser-Phe-Arg-Arg-Ala-Lys-Gln-OH |