251293-28-4

251293-28-4 structure

Name: Urotensin II (human) trifluoroacetate salt
Chemical Name: Urotensin II (human)
CAS Number: 251293-28-4
Molecular Formula: C₆₄H₈₅N₁₃O₁₈S₂
Molecular Weight: 1388.57
Catalog: Peptides
Create Date: 2018-12-09 20:46:12
Modify Date: 2024-01-08 02:04:36
Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

Name	Urotensin II (human)
Synonyms	m.w. 1388.57 c64h85n13o18s2 glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val hydrochloride glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val urotensin-ii h-glu-thr-pro-asp-cys-phe-trp-lys-tyr-cys-val-oh GLU-THR-PRO-ASP-CYS-PHE-TRP-LYS-TYR-CYS-VAL(DISULFIDE BRIDGE:CYS5-CYS10) Urotensin II (114-124), human

Description	Urotensin II (114-124), human, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.
Related Catalog	Signaling Pathways >> Others >> Others Peptides Research Areas >> Cardiovascular Disease
Target	GPR14[1]
In Vitro	Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].
In Vivo	Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].
References	[1]. Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.