Pregnenolone

Modify Date: 2024-01-02 12:28:29

Pregnenolone Structure
Pregnenolone structure
 Common Name Pregnenolone
CAS Number 145-13-1 Molecular Weight 316.478
Density 1.1±0.1 g/cm3 Boiling Point 443.3±45.0 °C at 760 mmHg
Molecular Formula C21H32O2 Melting Point 188-190 °C
MSDS Chinese USA Flash Point 188.9±21.3 °C
Symbol GHS02 GHS07
GHS02, GHS07		 Signal Word Danger

 Use of Pregnenolone


Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).

 Names

Name pregnenolone
Synonym More Synonyms

 Pregnenolone Biological Activity

Description Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor, reduces several effects of tetrahydrocannabinol (THC).
Related Catalog
Target

CB1 Receptor

Human Endogenous Metabolite
In Vitro The effect of THC is significantly attenuated when slices are pre-treated with Pregnenolone 100 nM (15.1±1.8 % of inhibition). These effects are likely due to a pre-synaptic action of Pregnenolone. Thus, Pregnenolone blocks the increase in paired-pulse ratio (PPR) induced by THC but does not modify either the amplitude or the decay time of miniature EPSC (mEPSC)[1].
In Vivo Pregnenolone administration (2-6 mg/kg) blocks THC-induced food-intake in Wistar rats and in C57BL/6N mice, and blunts the memory impairment induced by THC in mice, but it does not modify these behaviors per se. Injections of Pregnenolone (2 and 4mg/kg) before each self-administration session reduce the intake of WIN 55,212-2 and reduce the break-point in a progressive ratio schedule[1].
Animal Admin Mice and Rats[1] Adult male Wistar rats (weighing 320-340g), Sprague Dawley male rats (weighing 330-350g), C57BL/6N mice (2-3 months) and CD1 mice (weighing 25-30 g at the beginning of the experiments) are used. Pregnenolone is injected subcutaneously (sc). The injection volumes are 1 mL/kg of body weight for rats and 10 mL/kg for mice[1].
References

[1]. Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8.

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 443.3±45.0 °C at 760 mmHg
Melting Point 188-190 °C
Molecular Formula C21H32O2
Molecular Weight 316.478
Flash Point 188.9±21.3 °C
Exact Mass 316.240234
PSA 37.30000
LogP 4.52
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.550
Storage condition 2~8℃

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TU5560700
CHEMICAL NAME :
Pregn-5-en-20-one, 3-beta-hydroxy-
CAS REGISTRY NUMBER :
145-13-1
LAST UPDATED :
199609
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C21-H32-O2
MOLECULAR WEIGHT :
316.53

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 11,117,1968 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Parenteral
DOSE :
35 mg/kg
SEX/DURATION :
female 7 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - uterus, cervix, vagina
REFERENCE :
JEMEAV Journal of Experimental Medicine. (Rockefeller Univ. Press, 1230 York Ave., New York, NY 10021) V.1- 1896- Volume(issue)/page/year: 102,347,1955

 Safety Information

Symbol GHS02 GHS07
GHS02, GHS07
Signal Word Danger
Hazard Statements H225-H302 + H312 + H332-H319
Precautionary Statements P210-P280-P305 + P351 + P338
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS TU5560700
HS Code 2937290090

 Synthetic Route

 Customs

HS Code 2937290090

 Articles92

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 Synonyms

EINECS 205-647-4
prenolon
ZK-5553
MFCD00003628
Pregn-5-en-20-one, 3-hydroxy-
prenenolone
Pregnelone
Pregnenlolone
3-Hydroxypregn-5-en-20-one
Pregnenolone
3β-Hydroxy-5-pregnen-20-one
5-Pregnen-3β-ol-20-one
pregnolon
Progeserone
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Related Compounds: More...
Pregnenolone
38372-24-6
16-Pregnenolone
566-60-9
Pregnenolone-d4-1
61574-54-7
Pregnenolone-3-mtp
155538-87-7
3-epi-Pregnenolone
19037-28-6
3-epi-Pregnenolone
566-63-2
17-OH-pregnenolone
387-79-1
pregnenolone oleate
72205-39-1
ACETOXYPREGNENOLONE
1778-02-5
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