PARPi-FL

Modify Date: 2024-04-11 17:59:31

PARPi-FL structure	Common Name	PARPi-FL
	CAS Number	1380359-84-1	Molecular Weight	640.46
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₄H₃₂BF₃N₆O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PARPi-FL

PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo[1].

Name	PARPi-FL
Synonym	More Synonyms

Description	PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Ziadeh T, et al. Poly(ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22(18):1237-1250. [2]. Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16(5):432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23.

Description

PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo[1].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

References

[1]. Ziadeh T, et al. Poly(ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22(18):1237-1250.

[2]. Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16(5):432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23.

Molecular Formula	C₃₄H₃₂BF₃N₆O₃
Molecular Weight	640.46
Exact Mass	640.258118

(T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron

Boron, [4-[[3-[[4-[3-[2-[(3,5-dimethyl-1H-pyrrol-2-yl-κN)methylene]-2H-pyrrol-5-yl-κN]-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoro-

[4-(3-{[4-(3-{2-[(3,5-Dimethyl-1H-pyrrol-2-yl-κN)methylene]-2H-pyrrol-5-yl-κN}propanoyl)-1-piperazinyl]carbonyl}-4-fluorobenzyl)-1(2H)-phthalazinonato](difluoro)boron

Olaparib-Bodipy Fl

PARPi-FL

Use of PARPi-FL

Names

PARPi-FL Biological Activity

Chemical & Physical Properties

Synonyms