PARPi-FL

Names

[ CAS No. ]:
1380359-84-1

[ Name ]:
PARPi-FL

[Synonym ]:
(T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron
Boron, [4-[[3-[[4-[3-[2-[(3,5-dimethyl-1H-pyrrol-2-yl-κN)methylene]-2H-pyrrol-5-yl-κN]-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoro-
[4-(3-{[4-(3-{2-[(3,5-Dimethyl-1H-pyrrol-2-yl-κN)methylene]-2H-pyrrol-5-yl-κN}propanoyl)-1-piperazinyl]carbonyl}-4-fluorobenzyl)-1(2H)-phthalazinonato](difluoro)boron
Olaparib-Bodipy Fl

Biological Activity

[Description]:

PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> PARP
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[References]

[1]. Ziadeh T, et al. Poly(ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22(18):1237-1250.  

[2]. Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16(5):432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23.  

Chemical & Physical Properties

[ Molecular Formula ]:
C34H32BF3N6O3

[ Molecular Weight ]:
640.46

[ Exact Mass ]:
640.258118

Related Compounds