1380359-84-1

1380359-84-1 structure

Name: PARPi-FL
Chemical Name: PARPi-FL
CAS Number: 1380359-84-1
Molecular Formula: C₃₄H₃₂BF₃N₆O₃
Molecular Weight: 640.46
Catalog: Signaling Pathways Cell Cycle/DNA Damage PARP
Create Date: 2022-03-28 13:46:56
Modify Date: 2024-04-11 17:59:31
PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo[1].

Name	PARPi-FL
Synonyms	(T-4)-[4-[[3-[[4-[3-[5-[(3,5-Dimethyl-2H-pyrrol-2-ylidene-κN)methyl]-1H-pyrrol-2-yl-κN-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoroboron Boron, [4-[[3-[[4-[3-[2-[(3,5-dimethyl-1H-pyrrol-2-yl-κN)methylene]-2H-pyrrol-5-yl-κN]-1-oxopropyl]-1-piperazinyl]carbonyl]-4-fluorophenyl]methyl]-1(2H)-phthalazinonato]difluoro- [4-(3-{[4-(3-{2-[(3,5-Dimethyl-1H-pyrrol-2-yl-κN)methylene]-2H-pyrrol-5-yl-κN}propanoyl)-1-piperazinyl]carbonyl}-4-fluorobenzyl)-1(2H)-phthalazinonato](difluoro)boron Olaparib-Bodipy Fl

Description	PARPi-FL is a small molecule and fluorescent inhibitor of PARP1. PARPi-FL is a highly selective probe and can be used as an imaging agent to detect glioblastomas in vivo[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Epigenetics >> PARP Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
References	[1]. Ziadeh T, et al. Poly(ADP-ribose) polymerase inhibitors in prostate cancer: a cornerstone in precision oncology. Pharmacogenomics. 2021 Dec;22(18):1237-1250. [2]. Irwin CP, et al. PARPi-FL--a fluorescent PARP1 inhibitor for glioblastoma imaging. Neoplasia. 2014 May;16(5):432-40. doi: 10.1016/j.neo.2014.05.005. Epub 2014 Jun 23.