DBCO-Amine

Modify Date: 2024-01-04 16:49:58

DBCO-Amine structure	Common Name	DBCO-Amine
	CAS Number	1255942-06-3	Molecular Weight	276.33200
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₆N₂O	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	N/A

Use of DBCO-Amine

DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Name	Azadibenzocylooctyne-amine
Synonym	More Synonyms

Description	DBCO-amine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker
Target	Cleavable
In Vitro	ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
References	[1]. Ermira Pazolli, et al. Splicing modulator antibody-drug conjugates and methods of use. WO2019232449A1.

Molecular Formula	C₁₈H₁₆N₂O
Molecular Weight	276.33200
Exact Mass	276.12600
PSA	46.33000
LogP	3.04710
Storage condition	-20°C

RIDADR	NONH for all modes of transport

Rapid Cu-free click chemistry with readily synthesized biarylazacyclooctynones.

J. Am. Chem. Soc. 11th ed., 132 , 3688-3690, (2010)

Bioorthogonal chemical reactions, those that do not interact or interfere with biology, have allowed for exploration of numerous biological processes that were previously difficult to study. The react...

Copper-free click chemistry for dynamic in vivo imaging.

Proc. Natl. Acad. Sci. U. S. A. 43th ed., 104 , 16793-16797, (2007)

Dynamic imaging of proteins in live cells is routinely performed by using genetically encoded reporters, an approach that cannot be extended to other classes of biomolecules such as glycans and lipids...

Visualizing metabolically labeled glycoconjugates of living cells by copper-free and fast huisgen cycloadditions.

Angew. Chem. Int. Ed. Engl. 47 , 2253-2255, (2008)

Dibenzocyclooctyne-amine

DBCO-NH2

DBCO-amine

ADIBO-AMINE