(±)-Anatoxin A fumarate

Modify Date: 2024-01-07 17:19:30

(±)-Anatoxin A fumarate Structure
(±)-Anatoxin A fumarate structure
 Common Name (±)-Anatoxin A fumarate
CAS Number 1219922-30-1 Molecular Weight 281.304
Density N/A Boiling Point N/A
Molecular Formula C14H19NO5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (±)-Anatoxin A fumarate


(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].

 Names

Name 1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone (2E)-2-butenedioate (1:1)
Synonym More Synonyms

 (±)-Anatoxin A fumarate Biological Activity

Description (±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].
Related Catalog
Target

Ki: 1.25 nM ( α4β2 receptor) Ki: 1.84 μM ( α7 receptor)[1]

References

[1]. P Thomas, et al. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J Neurochem. 1993 Jun;60(6):2308-11.

 Chemical & Physical Properties

Molecular Formula C14H19NO5
Molecular Weight 281.304
Exact Mass 281.126312
PSA 103.70000
LogP 1.45680

 Synonyms

Ethanone, 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-, (2E)-2-butenedioate (1:1)
1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone (2E)-2-butenedioate (1:1)
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