1219922-30-1

1219922-30-1 structure

Name: (±)-Anatoxin A fumarate
Chemical Name: 1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone (2E)-2-butenedioate (1:1)
CAS Number: 1219922-30-1
Molecular Formula: C₁₄H₁₉NO₅
Molecular Weight: 281.304
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2016-10-05 21:50:45
Modify Date: 2024-01-07 17:19:30
(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].

Name	1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone (2E)-2-butenedioate (1:1)
Synonyms	Ethanone, 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-, (2E)-2-butenedioate (1:1) 1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone (2E)-2-butenedioate (1:1)

Description	(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
Target	Ki: 1.25 nM ( α4β2 receptor) Ki: 1.84 μM ( α7 receptor)[1]
References	[1]. P Thomas, et al. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J Neurochem. 1993 Jun;60(6):2308-11.