(±)-Anatoxin A fumarate

Names

[ CAS No. ]:
1219922-30-1

[ Name ]:
(±)-Anatoxin A fumarate

[Synonym ]:
Ethanone, 1-(9-azabicyclo[4.2.1]non-2-en-2-yl)-, (2E)-2-butenedioate (1:1)
1-(9-Azabicyclo[4.2.1]non-2-en-2-yl)ethanone (2E)-2-butenedioate (1:1)

Biological Activity

[Description]:

(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Research Areas >> Neurological Disease

[Target]

Ki: 1.25 nM ( α4β2 receptor) Ki: 1.84 μM ( α7 receptor)[1]

[References]

[1]. P Thomas, et al. (+)-Anatoxin-a is a potent agonist at neuronal nicotinic acetylcholine receptors. J Neurochem. 1993 Jun;60(6):2308-11.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₉NO₅

[ Molecular Weight ]:
281.304

[ Exact Mass ]:
281.126312

[ PSA ]:
103.70000

[ LogP ]:
1.45680

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.