Cyclic ADP-ribose
Cyclic ADP-ribose structure
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Common Name | Cyclic ADP-ribose | ||
|---|---|---|---|---|
| CAS Number | 119340-53-3 | Molecular Weight | 541.30000 | |
| Density | 2.57 g/cm3 | Boiling Point | 934.8ºC at 760 mmHg | |
| Molecular Formula | C15H21N5O13P2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 519.1ºC | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of Cyclic ADP-riboseCyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by a ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1]. |
| Name | cyclic ADP-ribose |
|---|---|
| Synonym | More Synonyms |
| Description | Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by a ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1]. |
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| Related Catalog | |
| Target |
Calcium mobilization[1] TRPM2 channels[1] Endogenous metabolite[1] |
| In Vitro | In cells, Cyclic ADP-ribose (cADPR) is an important player in processes such as: cell proliferation and differentiation, regulating e.g. expansion of human mesenchymal stem cells and hemopoietic progenitors, neuronal differentiation of PC12 cells, and cardiomyocyte differentiation of mouse embryonic stem cells[1]. |
| In Vivo | In mammals, Cyclic ADP-ribose (cADPR) is an important player in processes such as: inflammatory and immune responses, including neutrophil chemotaxis and T cell activation; smooth muscle cell contraction in arteries and bronchi, with participation in the hypoxic pulmonary vasoconstriction and in the pathogenesis of inflammatory/allergic airway diseases; myometrium contractility, eventually contributing to delivery; myocyte contraction in adult cardiac tissue, participating in angiotensin II- and β-adrenergic-induced cardiac hypertrophy and in isoproterenol-induced arrhythmias; endocrine and exocrine pancreatic secretion; and social behaviour in mice, including memory formation and spatial learning, related to oxytocin secretion and maybe to niacin deficiency[1]. Furthermore, Cyclic ADP-ribose (cADPR) is involved in egg activation and fertilization in ascidians and sea urchin, in early development in sea urchin, in abscisic acid signalling in sponges and plants, in cell fission in dinoflagellates, and in Toxoplasma gondii pathogenicity[1]. |
| References |
| Density | 2.57 g/cm3 |
|---|---|
| Boiling Point | 934.8ºC at 760 mmHg |
| Molecular Formula | C15H21N5O13P2 |
| Molecular Weight | 541.30000 |
| Flash Point | 519.1ºC |
| Exact Mass | 541.06100 |
| PSA | 276.92000 |
| Vapour Pressure | 0mmHg at 25°C |
| Index of Refraction | 1.959 |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi: Irritant; |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36 |
| RIDADR | NONH for all modes of transport |
|
~3%
Cyclic ADP-ribose CAS#:119340-53-3 |
| Literature: Gu, Qu-Ming; Sih, Charles J. Journal of the American Chemical Society, 1994 , vol. 116, # 17 p. 7481 - 7486 |
|
~17%
Cyclic ADP-ribose CAS#:119340-53-3 |
| Literature: Yamada, Shinji; Gu, Qu-Ming; Sih, Charles J. Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10787 - 10788 |
|
~%
Cyclic ADP-ribose CAS#:119340-53-3 |
| Literature: Graham, Steven M.; Macaya, Daniel J.; Sengupta, Raghuvir N.; Turner, Kevin B. Organic Letters, 2004 , vol. 6, # 2 p. 233 - 236 |
|
~28%
Cyclic ADP-ribose CAS#:119340-53-3 |
| Literature: Yamada, Shinji; Gu, Qu-Ming; Sih, Charles J. Journal of the American Chemical Society, 1994 , vol. 116, # 23 p. 10787 - 10788 |
| Precursor 3 | |
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| DownStream 0 | |
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Cyclic ADP-ribose requires CD38 to regulate the release of ATP in visceral smooth muscle.
FEBS J. 278 , 3095-3108, (2011) It is well established that the intracellular second messenger cADP-ribose (cADPR) activates Ca(2+) release from the sarcoplasmic reticulum through ryanodine receptors. CD38 is a multifunctional enzym... |
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β-Adrenergic receptor signaling increases NAADP and cADPR levels in the heart.
Biochem. Biophys. Res. Commun. 427(2) , 326-9, (2012) Evidence suggests that β-Adrenergic receptor signaling increases heart rate and force through not just cyclic AMP but also the Ca(2+)-releasing second messengers NAADP (nicotinic acid adenine dinucleo... |
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Pyridine nucleotide metabolites and calcium release from intracellular stores.
Adv. Exp. Med. Biol. 740 , 305-23, (2012) Ca(2+) signals are probably the most common intracellular signaling elements, controlling an extensive range of responses in virtually all cells. Many cellular stimuli, often acting at cell surface re... |
| cyclic ADP-D-ribose |
| Enzyme-activated NAD |
| adenosine 5'-cyclic-diphosphoribose |
| cyclic adenosine 5'-diphosphoribose |
| cADP-Ribose |
| Cyclic Adenosine Diphosphate Ribose |
| E-NAD |
| cADPR |
| Cyclic ADPR |
| cyclic adenosine 5'-diphosphate ribose |
| MFCD00214262 |