Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: CADP-RIBOSE
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119340-53-3

119340-53-3 structure

Name: Cyclic ADP-ribose
Chemical Name: cyclic ADP-ribose
CAS Number: 119340-53-3
Molecular Formula: C₁₅H₂₁N₅O₁₃P₂
Molecular Weight: 541.30000
Catalog: Signaling Pathways Membrane Transporter/Ion Channel Calcium Channel
Create Date: 2018-04-27 08:00:00
Modify Date: 2024-01-02 06:17:02
Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by a ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1].

Name	cyclic ADP-ribose
Synonyms	cyclic ADP-D-ribose Enzyme-activated NAD adenosine 5'-cyclic-diphosphoribose cyclic adenosine 5'-diphosphoribose cADP-Ribose Cyclic Adenosine Diphosphate Ribose E-NAD cADPR Cyclic ADPR cyclic adenosine 5'-diphosphate ribose MFCD00214262

Description	Cyclic ADP-ribose (cADPR) is a potent second messenger for calcium mobilization that is synthesized from NAD+ by a ADP-ribosyl cyclase. Cyclic ADP-ribose increases cytosolic calcium mainly by Ryanodine receptor-mediated release from endoplasmic reticulum and also by extracellular influx through the opening of TRPM2 channels[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> Calcium Channel Signaling Pathways >> Membrane Transporter/Ion Channel >> TRP Channel Research Areas >> Cardiovascular Disease Research Areas >> Endocrinology Research Areas >> Infection Research Areas >> Inflammation/Immunology Research Areas >> Neurological Disease
Target	Calcium mobilization[1] TRPM2 channels[1] Endogenous metabolite[1]
In Vitro	In cells, Cyclic ADP-ribose (cADPR) is an important player in processes such as: cell proliferation and differentiation, regulating e.g. expansion of human mesenchymal stem cells and hemopoietic progenitors, neuronal differentiation of PC12 cells, and cardiomyocyte differentiation of mouse embryonic stem cells[1].
In Vivo	In mammals, Cyclic ADP-ribose (cADPR) is an important player in processes such as: inflammatory and immune responses, including neutrophil chemotaxis and T cell activation; smooth muscle cell contraction in arteries and bronchi, with participation in the hypoxic pulmonary vasoconstriction and in the pathogenesis of inflammatory/allergic airway diseases; myometrium contractility, eventually contributing to delivery; myocyte contraction in adult cardiac tissue, participating in angiotensin II- and β-adrenergic-induced cardiac hypertrophy and in isoproterenol-induced arrhythmias; endocrine and exocrine pancreatic secretion; and social behaviour in mice, including memory formation and spatial learning, related to oxytocin secretion and maybe to niacin deficiency[1]. Furthermore, Cyclic ADP-ribose (cADPR) is involved in egg activation and fertilization in ascidians and sea urchin, in early development in sea urchin, in abscisic acid signalling in sponges and plants, in cell fission in dinoflagellates, and in Toxoplasma gondii pathogenicity[1].
References	[1]. Ribeiro JM, et al. Specific cyclic ADP-ribose phosphohydrolase obtained by mutagenic engineering of Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase. Sci Rep. 2018 Jan 18;8(1):1036.

Density	2.57 g/cm3
Boiling Point	934.8ºC at 760 mmHg
Molecular Formula	C₁₅H₂₁N₅O₁₃P₂
Molecular Weight	541.30000
Flash Point	519.1ºC
Exact Mass	541.06100
PSA	276.92000
Vapour Pressure	0mmHg at 25°C
Index of Refraction	1.959

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S36
RIDADR	NONH for all modes of transport