Diatrizoic acid

Modify Date: 2025-08-26 17:58:53

Diatrizoic acid Structure
Diatrizoic acid structure
Common Name Diatrizoic acid
CAS Number 117-96-4 Molecular Weight 613.914
Density 2.7±0.1 g/cm3 Boiling Point 720.2±70.0 °C at 760 mmHg
Molecular Formula C11H9I3N2O4 Melting Point >300ºC
MSDS Chinese USA Flash Point 389.4±35.7 °C

 Use of Diatrizoic acid


Diatrizoic acid is an iodinated radiocontrast agent.

 Names

Name amidotrizoic acid
Synonym More Synonyms

 Diatrizoic acid Biological Activity

Description Diatrizoic acid is an iodinated radiocontrast agent.
Related Catalog
In Vivo Diatrizoic acid is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Diatrizoic acid nanoparticle agglomerates. Diatrizoic acid nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1].
Animal Admin Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Diatrizoic acid nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1].
References

[1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12.

 Chemical & Physical Properties

Density 2.7±0.1 g/cm3
Boiling Point 720.2±70.0 °C at 760 mmHg
Melting Point >300ºC
Molecular Formula C11H9I3N2O4
Molecular Weight 613.914
Flash Point 389.4±35.7 °C
Exact Mass 613.769592
PSA 95.50000
LogP 1.53
Vapour Pressure 0.0±2.4 mmHg at 25°C
Index of Refraction 1.790
Storage condition Amber Vial, -20°C Freezer
Water Solubility Soluble in Methanol.

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG5950000
CHEMICAL NAME :
Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-
CAS REGISTRY NUMBER :
117-96-4
BEILSTEIN REFERENCE NO. :
2225144
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C11-H9-I3-N2-O4
MOLECULAR WEIGHT :
613.92
WISWESSER LINE NOTATION :
1VMR BI DI FI CVQ EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>12300 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,2411,1985
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
8900 mg/kg
TOXIC EFFECTS :
Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - weight loss or decreased weight gain
REFERENCE :
KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,2411,1985

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DG5950000
HS Code 2924299090

 Customs

HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

Amidotrizoic Acid,Diatrizoic acid
3,5-bis(acetylamino)-2,4,6-triiodobenzoic acid
3,5-Di(acetamido)-2,4,6-triiodobenzoic Acid
EINECS 204-223-6
3,5-diacetamido-2,4,6-triiodo-benzoic acid
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-
MFCD00069960
Amidotrizoic Acid
Urografin
2,4,6-Triiodo-3,5-diacetamidobenzoic acid
Gastrografin
3,5-Bis(acetamido)-2,4,6-triiodobenzoic Acid
Diatrizoic acid
3,5-Diacetamido-2,4,6-triiodobenzoic acid
Cardiografin
Diatrizoate
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