Diatrizoic acid

Names

[ CAS No. ]:
117-96-4

[ Name ]:
Diatrizoic acid

[Synonym ]:
Amidotrizoic Acid,Diatrizoic acid
3,5-bis(acetylamino)-2,4,6-triiodobenzoic acid
3,5-Di(acetamido)-2,4,6-triiodobenzoic Acid
EINECS 204-223-6
3,5-diacetamido-2,4,6-triiodo-benzoic acid
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-
MFCD00069960
Amidotrizoic Acid
Urografin
2,4,6-Triiodo-3,5-diacetamidobenzoic acid
Gastrografin
3,5-Bis(acetamido)-2,4,6-triiodobenzoic Acid
Diatrizoic acid
3,5-Diacetamido-2,4,6-triiodobenzoic acid
Cardiografin
Diatrizoate

Biological Activity

[Description]:

Diatrizoic acid is an iodinated radiocontrast agent.

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Others

[In Vivo]

Diatrizoic acid is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Diatrizoic acid nanoparticle agglomerates. Diatrizoic acid nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1].

[Animal admin]

Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Diatrizoic acid nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1].

[References]

[1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
2.7±0.1 g/cm3

[ Boiling Point ]:
720.2±70.0 °C at 760 mmHg

[ Melting Point ]:
>300ºC

[ Molecular Formula ]:
C₁₁H₉I₃N₂O₄

[ Molecular Weight ]:
613.914

[ Flash Point ]:
389.4±35.7 °C

[ Exact Mass ]:
613.769592

[ PSA ]:
95.50000

[ LogP ]:
1.53

[ Vapour Pressure ]:
0.0±2.4 mmHg at 25°C

[ Index of Refraction ]:
1.790

[ Storage condition ]:
Amber Vial, -20°C Freezer

[ Water Solubility ]:
Soluble in Methanol.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG5950000

CHEMICAL NAME :: Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-

CAS REGISTRY NUMBER :: 117-96-4

BEILSTEIN REFERENCE NO. :: 2225144

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H9-I3-N2-O4

MOLECULAR WEIGHT :: 613.92

WISWESSER LINE NOTATION :: 1VMR BI DI FI CVQ EMV1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >12300 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,2411,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8900 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - ptosis Lungs, Thorax, or Respiration - respiratory stimulation Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 19,2411,1985

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG5950000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

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