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737-31-5

737-31-5 structure
737-31-5 structure
Name sodium amidotrizoate
Synonyms Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, sodium salt
Sodium 3,5-diacetamido-2,4,6-triiodobenzoate
EINECS 212-004-1
win8308-3
MFCD00051544
3,5-Bis(acetylamino)-2,4,6-triiodobenzoic Acid Sodium Salt
Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, monosodium salt
Diatrizoate sodium salt
HYPAQUE SODIUM
3,5-diacetamido-2,4,6-triiodobenzoic acid sodium salt
gastrografin
histopaque
sodium 3,5-bis(acetylamino)-2,4,6-triiodobenzoate
hypaque
diatrizoate
Amidotrizoate Sodium
Radioselectan
triombrine
hypaque50
diatrizoic acid sodium salt
Sodium diatrizoate
Conray 35
3,5-bis-acetylamino-2,4,6-triiodo-benzoic acid,sodium-salt
sodium amidotrizoate
Urografic Acid Sodium Salt
Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, sodium salt (1:1)
Diatrizoate Sodium
Description Sodium diatrizoate is an iodinated radiocontrast agent.
Related Catalog
In Vivo Sodium diatrizoate is an iodinated radiocontrast agent. Histological examination of rat lung tissue shows no acute toxicity or inflammation after insufflation of Sodium diatrizoate nanoparticle agglomerates. Sodium diatrizoate nanoparticle agglomerates offers a promising radiocontrast agent for safe and effective lung visualization[1].
Animal Admin Female Sprague-Dawley rats (200 to 250 grams) are housed in temperature and humidity controlled rooms with free access to food and water and maintained on a 12 h light/dark cycle. Rats are anesthetized by a 67.5 mg/kg ketamine, 3.5 mg/kg xylazine and 0.66 mg/kg acepromazine subcutaneous cocktail. While under anesthesia, rats are placed on a heating pad to maintain a body temperature of 37°C. Sodium diatrizoate nanoparticle agglomerates (10 mg) is administered by intratracheal insufflation using a dry powder insufflator. At the end of the experiment, the rats are euthanized by isoflurane inhalation overdose followed by harvest of major organs[1].
References

[1]. El-Gendy N, et al. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. Int J Pharm. 2010 May 31;391(1-2):305-12.

Boiling Point 614.1ºC at 760 mmHg
Molecular Formula C11H8I3N2NaO4
Molecular Weight 635.895
Flash Point 325.2ºC
Exact Mass 635.751587
PSA 98.33000
LogP 1.92670
Water Solubility H2O: 0.35 g/mL, slightly turbid, colorless

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DG6125000
CHEMICAL NAME :
Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, monosodium salt
CAS REGISTRY NUMBER :
737-31-5
LAST UPDATED :
199710
DATA ITEMS CITED :
15
MOLECULAR FORMULA :
C11-H8-I3-N2-O4.Na
MOLECULAR WEIGHT :
635.90
WISWESSER LINE NOTATION :
1VMR BI DI FI CVO EMV1 &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>7 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
11400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>7 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
14 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20349 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
13200 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea Gastrointestinal - nausea or vomiting
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - cat
DOSE/DURATION :
11300 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CLDND* Compilation of LD50 Values of New Drugs. (J.R. MacDougal, Dept. of National Health and Welfare, Food and Drug Divisions, 35 John St., Ottawa, Ont., Canada)
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
12200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Human Lymphocyte
DOSE/DURATION :
2000 ppm
REFERENCE :
RADLAX Radiology. (Radiological Soc. of North America, 20th & Northampton Sts., Easton, PA 18042) V.1- 1923- Volume(issue)/page/year: 129,199,1978 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0840 No. of Facilities: 305 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 2285 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0840 No. of Facilities: 941 (estimated) No. of Industries: 1 No. of Occupations: 8 No. of Employees: 22494 (estimated) No. of Female Employees: 15852 (estimated)
Symbol GHS08
GHS08
Signal Word Danger
Hazard Statements H317-H334
Precautionary Statements P261-P280-P284-P304 + P340-P342 + P311
Hazard Codes Xn:Harmful
Risk Phrases R42/43
Safety Phrases S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS DG6125000
HS Code 2924299090
HS Code 2924299090
Summary 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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title: CAS No. 737-31-5 | Chemsrc address: https://www.chemsrc.com/en/baike/946714.html

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