ITK antagonist
Modify Date: 2025-10-07 13:55:17
ITK antagonist structure
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Common Name | ITK antagonist | ||
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| CAS Number | 1149753-56-9 | Molecular Weight | 494.65200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C26H34N6O2S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of ITK antagonistITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1]. |
| Name | (S)-N-(5-(((3,3-dimethylbutan-2-yl)amino)methyl)-1-(2-hydroxy-2-methylpropyl)-1H-benzo[d]imidazol-2(3H)-ylidene)-5-(1H-pyrazol-4-yl)thiophene-2-carboxamide |
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| Synonym | More Synonyms |
| Description | ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1]. |
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| Related Catalog | |
| In Vitro | ITK antagonist inhibits DT40 cell (IC50=4 nM) and shows IL-2 inhibition (IC50=20 nM)[1]. |
| References |
| Molecular Formula | C26H34N6O2S |
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| Molecular Weight | 494.65200 |
| Exact Mass | 494.24600 |
| PSA | 139.33000 |
| LogP | 4.84810 |
| itk antagonist |