ITK antagonist

Names

[ Name ]:
ITK antagonist

[Synonym ]:
itk antagonist

Biological Activity

[Description]:

ITK antagonist (compound 10 n) is a potent, orally active and selective ITK (Interleukin-2 inducible T-cell kinase) antagonist (IC50=1 and 20 nM in different assays). ITK antagonist inhibits insulin receptor kinase (IRK) with an IC50 of 160 nM[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> Itk

[In Vitro]

ITK antagonist inhibits DT40 cell (IC50=4 nM) and shows IL-2 inhibition (IC50=20 nM)[1].

[References]

[1]. Riether D, et al. 5-Aminomethylbenzimidazoles as potent ITK antagonists. Bioorg Med Chem Lett. 2009;19(6):1588-1591.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₆H₃₄N₆O₂S

[ Molecular Weight ]:
494.65200

[ Exact Mass ]:
494.24600

[ PSA ]:
139.33000

[ LogP ]:
4.84810

Related Compounds

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