TSHR antagonist S37

Modify Date: 2025-08-25 18:50:41

TSHR antagonist S37 Structure
TSHR antagonist S37 structure
 Common Name TSHR antagonist S37
CAS Number 1217616-61-9 Molecular Weight 460.57
Density N/A Boiling Point N/A
Molecular Formula C25H20N2O3S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of TSHR antagonist S37


TSHR antagonist S37 is a selective and competitive thyrotropin receptor (TSHR) antagonist. TSHR antagonist S37 is the racemate of TSHR antagonist S37a[1].

 Names

Name TSHR antagonist S37

 TSHR antagonist S37 Biological Activity

Description TSHR antagonist S37 is a selective and competitive thyrotropin receptor (TSHR) antagonist. TSHR antagonist S37 is the racemate of TSHR antagonist S37a[1].
Related Catalog
Target

TSHR[1]

In Vitro TSHR antagonist S37 reduces also cAMP activation induced by the small molecule agonist C2[1]. TSHR antagonist S37 (10-100 µM) does not affect cell viability in the concentration range for the Hek293T-TSHR cell line[1].
References

[1]. Marcinkowski P, et al. A New Highly Thyrotropin Receptor-Selective Small-Molecule Antagonist with Potential for the Treatment of Graves' Orbitopathy. Thyroid. 2019 Jan;29(1):111-123.

 Chemical & Physical Properties

Molecular Formula C25H20N2O3S2
Molecular Weight 460.57
InChIKey YGFJFPYQZCZNIH-UHFFFAOYSA-N
SMILES O=C1C2C3CC(C2C(=O)N1c1ccccc1)C1C(c2ccccc2)c2sc(=O)[nH]c2SC31
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Chemsrc provides TSHR antagonist S37(CAS#:1217616-61-9) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of TSHR antagonist S37 are included as well.>> amp version: TSHR antagonist S37

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