Danofloxacine

Modify Date: 2024-01-05 12:38:45

Danofloxacine structure	Common Name	Danofloxacine
	CAS Number	112398-08-0	Molecular Weight	357.379
	Density	1.5±0.1 g/cm3	Boiling Point	569.3±50.0 °C at 760 mmHg
	Molecular Formula	C₁₉H₂₀FN₃O₃	Melting Point	268-272ºC
	MSDS	Chinese USA	Flash Point	298.1±30.1 °C

Use of Danofloxacine

Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment[1][2].

Name	Danofloxacin
Synonym	More Synonyms

Description	Danofloxacin is a third generation fluoroquinolone and orally active antimicrobial agent. Danofloxacin shows a broad spectrum of activity against most Gram-negative and Gram-positive bacteria, mycoplasma and chlamydia species, and plays an antimicrobial role by inhibition of bacterial DNA-gyrase. Danofloxacinh has the potential for respiratory diseases in cattle, swine, and chickens treatment[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis Signaling Pathways >> Anti-infection >> Bacterial
References	[1]. Erjie Tian, et al. Population Pharmacokinetics for Danofloxacin in the Intestinal Contents of Healthy and Infected Chickens. J Vet Pharmacol Ther. 2019 Sep;42(5):556-563. [2]. Xia Xiao, et al. Comparative Pharmacokinetics of Danofloxacin in Healthy and Pasteurella Multocida Infected Ducks. J Vet Pharmacol Ther. 2018 Dec;41(6):912-918.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis

Signaling Pathways >> Anti-infection >> Bacterial

References

[1]. Erjie Tian, et al. Population Pharmacokinetics for Danofloxacin in the Intestinal Contents of Healthy and Infected Chickens. J Vet Pharmacol Ther. 2019 Sep;42(5):556-563.

[2]. Xia Xiao, et al. Comparative Pharmacokinetics of Danofloxacin in Healthy and Pasteurella Multocida Infected Ducks. J Vet Pharmacol Ther. 2018 Dec;41(6):912-918.

Density	1.5±0.1 g/cm3
Boiling Point	569.3±50.0 °C at 760 mmHg
Melting Point	268-272ºC
Molecular Formula	C₁₉H₂₀FN₃O₃
Molecular Weight	357.379
Flash Point	298.1±30.1 °C
Exact Mass	357.148865
PSA	65.78000
LogP	1.20
Vapour Pressure	0.0±1.6 mmHg at 25°C
Index of Refraction	1.679
Water Solubility	Soluble in water, acetic acid and DMSO

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn,Xi
Risk Phrases	20/21/22-36/37/38
Safety Phrases	22-24/25
RIDADR	NONH for all modes of transport

1-CYCLOPROPYL-6...

CAS#:93107-30-3

2-Methyl-2,5-di...

CAS#:52321-26-3

~78%

Danofloxacine

CAS#:112398-08-0

Literature: McGuirk; Jefson; Mann; Elliott; Chang; Cisek; Cornell; Gootz; Haskell; Hindahl; LaFleur; Rosenfeld; Shryock; Silvia; Weber Journal of Medicinal Chemistry, 1992 , vol. 35, # 4 p. 611 - 620

Precursor 1
CAS#:93107-30-3 1-CYCLOPROPYL-6...
DownStream 0

Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry.

J. Chromatogr. A. 1379 , 83-91, (2015)

This work involved the optimization and validation of two methods according to the Commission Decision 2002/657/EC directives for determining fluoroquinolones residues in samples of poultry muscle and...

Simultaneous determination of 38 veterinary antibiotic residues in raw milk by UPLC-MS/MS.

Food Chem. 181 , 119-26, (2015)

A selective and rapid method has been developed to determine, simultaneously, 38 veterinary antibiotic residues in raw milk by ultra-high-performance liquid chromatography-tandem mass spectrometry (UP...

Decay mechanisms of protonated 4-quinolone antibiotics after electrospray ionization and ion activation.

J. Am. Soc. Mass Spectrom. 25(11) , 1974-86, (2014)

This study presents a detailed experimental investigation of charge isomers of protonated 4-quinolone antibiotics molecules formed during electrospray ionization (ESI) with proposed dissociation mecha...

1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid

danofloxacin

3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-

1-Cyclopropyl-6-fluoro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

(1S)-1-Cyclopropyl-6-fluoro-1,4-dihydro-7-(5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl)-4-oxo-3-quinolinecarboxylic acid

DC Chemicals Limited
China
Product Name: Danofloxacine
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 3-Quinolinecarboxylicacid,1-cyclopropyl-6-fluoro-1,4-dihydro-7-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]hept-2-yl]-4-oxo-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Danofloxacine

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