622402-22-6
622402-22-6 structure
- Name: GW590735
- Chemical Name: gw 590735
- CAS Number: 622402-22-6
- Molecular Formula: C23H21F3N2O4S
- Molecular Weight: 478.484
- Create Date: 2017-09-30 08:23:26
- Modify Date: 2025-08-21 18:23:54
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GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.
| Name | gw 590735 |
|---|---|
| Synonyms |
2-Methyl-2-(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenoxy)propanoic acid
2-methyl-2-(4-(((4-methyl-2-(4-trifluoromethylphenyl)-thiazol-5-ylcarbonyl)amino)methyl)phenoxy)propionic acid Propanoic acid, 2-methyl-2-[4-[[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]carbonyl]amino]methyl]phenoxy]- |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H21F3N2O4S |
| Molecular Weight | 478.484 |
| Exact Mass | 478.117401 |
| PSA | 116.76000 |
| LogP | 5.22 |
| Index of Refraction | 1.572 |