GW590735
Modify Date: 2025-08-21 18:23:54
GW590735 structure
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Common Name | GW590735 | ||
|---|---|---|---|---|
| CAS Number | 622402-22-6 | Molecular Weight | 478.484 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C23H21F3N2O4S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of GW590735GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively. |
| Name | gw 590735 |
|---|---|
| Synonym | More Synonyms |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Molecular Formula | C23H21F3N2O4S |
| Molecular Weight | 478.484 |
| Exact Mass | 478.117401 |
| PSA | 116.76000 |
| LogP | 5.22 |
| Index of Refraction | 1.572 |
| 2-Methyl-2-(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenoxy)propanoic acid |
| 2-methyl-2-(4-(((4-methyl-2-(4-trifluoromethylphenyl)-thiazol-5-ylcarbonyl)amino)methyl)phenoxy)propionic acid |
| Propanoic acid, 2-methyl-2-[4-[[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]carbonyl]amino]methyl]phenoxy]- |