217950-62-4
217950-62-4 structure
- Name: GW 275175X
- Chemical Name: GW 275175X
- CAS Number: 217950-62-4
- Molecular Formula: C12H11BrCl2N2O4
- Molecular Weight: 398.034
- Create Date: 2020-01-11 18:45:50
- Modify Date: 2024-07-22 14:11:41
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GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation; shows antiviral efficacy against AD169 laboratory strain in DNA hybridization assays with IC50 of 0.7 uM, against 10 clinically relevant HCMV isolates with IC50 of 0.16-2.21 uM, and little or no activity against HSV-1, HSV-2 and varicella zoster virus; inhibits viral DNA maturation in a dose-dependent fashion.
| Name | GW 275175X |
|---|
| Description | GW 275175X is a derivative of BDCRB that displays anti-HCMV activity by inhibition of viral DNA maturation; shows antiviral efficacy against AD169 laboratory strain in DNA hybridization assays with IC50 of 0.7 uM, against 10 clinically relevant HCMV isolates with IC50 of 0.16-2.21 uM, and little or no activity against HSV-1, HSV-2 and varicella zoster virus; inhibits viral DNA maturation in a dose-dependent fashion. |
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| References | References 1. Williams SL, et al. Antimicrob Agents Chemother. 2003 Jul;47(7):2186-92. 2. Underwood MR, et al. Antimicrob Agents Chemother. 2004 May;48(5):1647-51. View Related Products by Target CMV |
| Molecular Formula | C12H11BrCl2N2O4 |
|---|---|
| Molecular Weight | 398.034 |