221148-46-5

221148-46-5 structure

Name: GW-406381
Chemical Name: 2-(4-ethoxyphenyl)-3-(4-methylsulfonylphenyl)pyrazolo[1,5-b]pyridazine
CAS Number: 221148-46-5
Molecular Formula: C₂₁H₁₉N₃O₃S
Molecular Weight: 393.45900
Catalog: Signaling Pathways Immunology/Inflammation COX
Create Date: 2018-06-21 14:29:06
Modify Date: 2025-08-26 11:13:59
GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury[1][2].

Name	2-(4-ethoxyphenyl)-3-(4-methylsulfonylphenyl)pyrazolo[1,5-b]pyridazine
Synonyms	Pyrazolo(1,5-b)pyridazine,2-(4-ethoxyphenyl)-3-(4-(methylsulfonyl)phenyl)

Description	GW406381, a highly selective cyclooxygenase-2 (COX-2) inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury[1][2].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> Immunology/Inflammation >> COX Research Areas >> Neurological Disease
Target	COX-2
References	[1]. Zhao FY, et al. GW406381, a novel COX-2 inhibitor, attenuates spontaneous ectopic discharge in sural nerves of rats following chronic constriction injury. Pain. 2007 Mar;128(1-2):78-87. [2]. Boswell DJ, et al. Evaluation of GW406381 for treatment of osteoarthritis of the knee: two randomized, controlled studies. Medscape J Med. 2008;10(11):259.