408303-44-6
408303-44-6 structure
- Name: GW-766994 R-form
- Chemical Name: 4-{[({[(2R)-4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}carbamoyl)amino]methyl}benzamide
- CAS Number: 408303-44-6
- Molecular Formula: C21H24Cl2N4O3
- Molecular Weight: 451.346
- Create Date: 2020-01-11 09:20:57
- Modify Date: 2023-01-30 22:06:01
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GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures.
| Name | 4-{[({[(2R)-4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}carbamoyl)amino]methyl}benzamide |
|---|---|
| Synonyms |
4-{[({[(2R)-4-(3,4-Dichlorobenzyl)-2-morpholinyl]methyl}carbamoyl)amino]methyl}benzamide
Benzamide, 4-[[[[[[(2R)-4-[(3,4-dichlorophenyl)methyl]-2-morpholinyl]methyl]amino]carbonyl]amino]methyl]- |
| Description | GW-766994 (GW766994) is a potent, selective, orally available CCR3 antagonist with pKi of 7.86 for inhibiting eotaxin-induced eosinophil chemotaxis in vitro assays; reverses CCL11-induced activation of CDK5 at 10 uM in rat neurons expressed CCR3, blocks CCL11-induced the production of Aβ and dendritic spine loss in the hippocampal neuronal cultures. |
|---|---|
| References | References 1. Neighbour H, et al. Clin Exp Allergy. 2014 Apr;44(4):508-16. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 685.8±55.0 °C at 760 mmHg |
| Molecular Formula | C21H24Cl2N4O3 |
| Molecular Weight | 451.346 |
| Flash Point | 368.5±31.5 °C |
| Exact Mass | 450.122559 |
| LogP | 1.50 |
| Vapour Pressure | 0.0±2.1 mmHg at 25°C |
| Index of Refraction | 1.608 |