622402-22-6

• 常用中文名：GW590735
• 常用英文名：GW590735
• CAS号：622402-22-6
• 分子式：C₂₃H₂₁F₃N₂O₄S
• 分子量：478.484
• 发布时间：2017-09-30 08:23:26
• 更新时间：2025-08-21 18:23:54
• GW590735 is a potent and selective agonist of PPARα with an EC50 value of 4 nM for the expression a GAL4-responsive reporter gene and at least 500-fold selectivity versus PPARγ and PPARδ. GW590735 significantly increased HDL cholesterol, decreased LDL and VLDL cholesterol, and significantly reduced triglycerides. Maximal increases in HDL cholesterol were 37%, 53%, and 84% with fenofibrate, torcetrapib, and GW590735, respectively.

名称

• 英文名: gw 590735
• 英文别名: 2-Methyl-2-(4-{[({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}carbonyl)amino]methyl}phenoxy)propanoic acid; 2-methyl-2-(4-(((4-methyl-2-(4-trifluoromethylphenyl)-thiazol-5-ylcarbonyl)amino)methyl)phenoxy)propionic acid; Propanoic acid, 2-methyl-2-[4-[[[[4-methyl-2-[4-(trifluoromethyl)phenyl]-5-thiazolyl]carbonyl]amino]methyl]phenoxy]-

物化性质

• 密度: 1.3±0.1 g/cm3
• 分子式: C₂₃H₂₁F₃N₂O₄S
• 分子量: 478.484
• 精确质量: 478.117401
• PSA: 116.76000
• LogP: 5.22
• 折射率: 1.572