636-58-8
636-58-8 structure
- Name: Gamma-glutamylcysteine
- Chemical Name: L-γ-glutamyl-L-cysteine
- CAS Number: 636-58-8
- Molecular Formula: C8H14N2O5S
- Molecular Weight: 250.27200
- Catalog: Biochemical Amino acids and their derivatives Glutamic acid derivative
- Create Date: 2018-04-29 08:00:00
- Modify Date: 2025-08-22 07:35:43
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Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels[1].
| Name | L-γ-glutamyl-L-cysteine |
|---|---|
| Synonyms |
Glutathione Impurity D
L-gamma-glutamyl-L-cysteine (2S)-2-amino-5-[[(1R)-1-carboxy-2-sulfanylethyl]amino]-5-oxopentanoic acid g-L-Glutamyl-L-cysteine 5-L-Glutamyl-L-cysteine (S)-2-amino-5-(((R)-1-carboxy-2-mercaptoethyl)amino)-5-oxopentanoic acid (Des-Gly)-Glutathione (reduced) |
| Description | Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). Gamma-glutamylcysteine is a cofactor for glutathione peroxidase (GPx) to increase GSH levels[1]. |
|---|---|
| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | Co-treatment of Aβ40 oligomers with Gamma-glutamylcysteine (γ-Glutamylcysteine; GGC) at 200 μM increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) and leads to significant increases in the levels of the total antioxidant capacity (TAC) and GSH and reduces the GSSG/GSH ratio. Gamma-glutamylcysteine also upregulates the level of the anti-inflammatory cytokine IL-10 and reduced the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1]. |
| References |
| Density | 1.436g/cm3 |
|---|---|
| Boiling Point | 592.4ºC at 760 mmHg |
| Melting Point | 167℃ |
| Molecular Formula | C8H14N2O5S |
| Molecular Weight | 250.27200 |
| Flash Point | 312.1ºC |
| Exact Mass | 250.06200 |
| PSA | 168.52000 |
| Index of Refraction | 1.57 |
| Storage condition | −20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P261-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| Precursor 9 | |
|---|---|
| DownStream 2 | |
