283159-88-6

283159-88-6 structure

Name: Gamma-glutamylcysteine TFA
Chemical Name: Gamma-glutamylcysteine (TFA)
CAS Number: 283159-88-6
Molecular Formula: C₁₀H₁₅F₃N₂O₇S
Molecular Weight: 364.30
Catalog: Signaling Pathways Apoptosis TNF Receptor
Create Date: 2019-09-07 10:52:16
Modify Date: 2025-09-18 16:09:28
Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1].

Name	Gamma-glutamylcysteine (TFA)

Description	Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> Interleukin Related Research Areas >> Inflammation/Immunology Signaling Pathways >> Apoptosis >> TNF Receptor
Target	IL-10 IL-6 IL-1β TNF-α
References	[1]. Braidy N, et al. The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes. Front Aging Neurosci. 2019 Aug 8;11:177.