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70-18-8

70-18-8 structure
70-18-8 structure
Name Glutathione
Synonyms L-Glutathione Reduced
Tathion
L-Norvaline, 5-[[(1R,2Z)-2-[(carboxymethyl)imino]-2-hydroxy-1-(mercaptomethyl)ethyl]imino]-5-hydroxy-, (5Z)-
(5Z)-5-({(1Z,2R)-1-[(Carboxymethyl)imino]-1-hydroxy-3-sulfanyl-2-propanyl}imino)-5-hydroxy-L-norvaline
Deltathione
Glycine, N- (N-L-γ-glutamyl-L-cysteinyl)-
L-γ-Glutamyl-L-cysteinylglycine
Copren
Glycine, L-γ-glutamyl-L-cysteinyl-
Isethion
Glutathione reduced
GSH
Glutathione
Reduced glutathione
(2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-1-oxo-3-sulfanylpropan-2-yl]amino]-5-oxopentanoic acid
L-γ-Glutamyl-L-cysteiylglycin
Glutathiol
MFCD00065939
EINECS 200-725-4
(2S)-2-Amino-5-({(2R)-1-[(carboxymethyl)amino]-1-oxo-3-sulfanyl-2-propanyl}amino)-5-oxopentanoic acid
Glutathione-SH
N-(N-L-g-Glutamyl-L-cysteinyl)glycine
Glutinal
L-Glutathione
γ-glutamyl-cysteinyl-glycine
Description L-Glutathione reduced (GSH; γ-L-Glutamyl-L-cysteinyl-glycine) is an endogenous antioxidant and is capable of scavenging oxygen-derived free radicals.
Related Catalog
Target

Human Endogenous Metabolite

In Vitro L-Glutathione reduced is a non-protein thiol widely exists in living cells. L-Glutathione reduced plays important biological functions in the organism, including protein and DNA synthesis, enzyme activity, metabolism and cell protection. L-Glutathione reduced is capable of scavenging oxygen-derived free radicals and is established to be a marker of oxidative stress[1].
References

[1]. Pereira-Rodrigues N, et al. Electrocatalytic activity of cobalt phthalocyanine CoPc adsorbed on a graphite electrode for the oxidation of reduced L-glutathione (GSH) and the reduction of its disulfide (GSSG) at physiological pH. Bioelectrochemistry. 2007 Jan;70(1):147-54.
Density 1.4±0.1 g/cm3
Boiling Point 754.5±60.0 °C at 760 mmHg
Melting Point 182-192ºC
Molecular Formula C10H17N3O6S
Molecular Weight 307.323
Flash Point 410.1±32.9 °C
Exact Mass 307.083801
PSA 197.62000
LogP -0.87
Vapour Pressure 0.0±5.5 mmHg at 25°C
Index of Refraction 1.572

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC0556000
CHEMICAL NAME :
Glycine, N-(N-L-gamma-glutamyl-L-cysteinyl)-
CAS REGISTRY NUMBER :
70-18-8
LAST UPDATED :
199710
DATA ITEMS CITED :
20
MOLECULAR FORMULA :
C10-H17-N3-O6-S
MOLECULAR WEIGHT :
307.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4020 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2238 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
1250 mg/kg
SEX/DURATION :
female 1-22 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

MUTATION DATA

TYPE OF TEST :
DNA inhibition
TEST SYSTEM :
Mammal - species unspecified Lymphocyte
DOSE/DURATION :
10 mmol/L
REFERENCE :
CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 31,265,1980 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 83371 No. of Facilities: 174 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 1744 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 83371 No. of Facilities: 238 (estimated) No. of Industries: 1 No. of Occupations: 7 No. of Employees: 3078 (estimated) No. of Female Employees: 2121 (estimated)
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi: Irritant;
Risk Phrases R68
Safety Phrases S24/25
RIDADR NONH for all modes of transport
WGK Germany 2
RTECS MC0556000
HS Code 2930909090
HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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title: CAS No. 70-18-8 | Chemsrc address: https://www.chemsrc.com/en/baike/521820.html

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