| Name | Apigenin 7-glucuronide |
|---|---|
| Synonyms |
Apigenin 7-O-glucuronide
5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranosiduronic acid (2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxane-2-carboxylic acid 4H-1-Benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)- |
| Description | Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively. |
|---|---|
| Related Catalog | |
| Target |
MMP-3:12.87 μM (IC50) MMP-8:22.39 μM (IC50) MMP-9:17.52 μM (IC50) MMP13:0.27 μM (IC50) |
| In Vitro | Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively [1]. Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups[2]. |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 841.8±65.0 °C at 760 mmHg |
| Melting Point | >300℃ |
| Molecular Formula | C21H18O11 |
| Molecular Weight | 446.361 |
| Flash Point | 299.0±27.8 °C |
| Exact Mass | 446.084900 |
| PSA | 187.12000 |
| LogP | -0.55 |
| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
| Index of Refraction | 1.740 |
| Storage condition | ?20°C |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
|
~%
29741-09-1 |
| Literature: Phytochemistry, , vol. 71, # 7 p. 726 - 735 |