Top Suppliers:I want be here



29741-09-1

29741-09-1 structure
29741-09-1 structure
  • Name: Apigenin-7-glucuronide
  • Chemical Name: Apigenin 7-glucuronide
  • CAS Number: 29741-09-1
  • Molecular Formula: C21H18O11
  • Molecular Weight: 446.361
  • Catalog: Biochemical Chinese herbal medicine ingredients
  • Create Date: 2018-10-04 17:51:25
  • Modify Date: 2025-08-20 11:11:56
  • Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.

Name Apigenin 7-glucuronide
Synonyms Apigenin 7-O-glucuronide
5-Hydroxy-2-(4-hydroxyphenyl)-4-oxo-4H-chromen-7-yl β-D-glucopyranosiduronic acid
(2S,3S,4S,5R,6S)-3,4,5-trihydroxy-6-[5-hydroxy-2-(4-hydroxyphenyl)-4-oxochromen-7-yl]oxyoxane-2-carboxylic acid
4H-1-Benzopyran-4-one, 7-(β-D-glucopyranuronosyloxy)-5-hydroxy-2-(4-hydroxyphenyl)-
Description Apigenin-7-glucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively.
Related Catalog
Target

MMP-3:12.87 μM (IC50)

MMP-8:22.39 μM (IC50)

MMP-9:17.52 μM (IC50)

MMP13:0.27 μM (IC50)

In Vitro Apigenin-7-Oglucuronide could inhibit Matrix Metalloproteinases (MMP) activities, with IC50s of 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively [1]. Scutellarin A also inhibits the migrated capacity of ACHN and 786-O cells in a dose-dependent manner. It is also revealed that after treatment with Scutellarin A (30, 60, and 90 μM) for 24 h, the apoptosis rates in ACHN and 786-O cells are remarkably enhanced dose-dependently when compared to the control groups[2].
References

[1]. Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911.

[2]. Deng W, et al. Scutellarin inhibits human renal cancer cell proliferation and migration via upregulation of PTEN. Biomed Pharmacother. 2018 Nov;107:1505-1513.

Density 1.7±0.1 g/cm3
Boiling Point 841.8±65.0 °C at 760 mmHg
Melting Point >300℃
Molecular Formula C21H18O11
Molecular Weight 446.361
Flash Point 299.0±27.8 °C
Exact Mass 446.084900
PSA 187.12000
LogP -0.55
Vapour Pressure 0.0±3.3 mmHg at 25°C
Index of Refraction 1.740
Storage condition ?20°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Hazard Codes Xn
Risk Phrases 22
RIDADR NONH for all modes of transport
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.