2089293-81-0
2089293-81-0 structure
- Name: NAcM-COV
- Chemical Name: NAcM-COV
- CAS Number: 2089293-81-0
- Molecular Formula: C28H35F3N4O2
- Molecular Weight: 516.609
- Create Date: 2020-01-19 20:03:56
- Modify Date: 2024-01-30 19:16:40
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NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays; shows highly selectivity with respect to other protein acetyl-amide-binding sites; inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification.
| Name | NAcM-COV |
|---|
| Description | NAcM-COV is a specific, irreversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 28 nM in TR-FRET assays; shows highly selectivity with respect to other protein acetyl-amide-binding sites; inhibits NEDD8 ligation in vitro and in cells, and suppress anchorage-independent growth of a cell line with DCN1 amplification. |
|---|---|
| References | References 1. Scott DC, et al. Nat Chem Biol. 2017 Aug;13(8):850-857. View Related Products by Target Ubiquitin-conjugating Enzyme (E2) |
| Molecular Formula | C28H35F3N4O2 |
|---|---|
| Molecular Weight | 516.609 |