Shanghai Nianxing Industrial Co., Ltd
China
Product Name: NAcM-OPT
Price: Check
Purity: 98.0%
Stocking Period: 10 Day
Contact: Yang
Email: sales@echemcloud.com

ShangHai DC Chemicals Co.,Ltd
China
Product Name: NAcM-OPT
Price: ￥Inquiry/1g
Purity: 98.9%
Stocking Period: 1 Day
Contact: Tony Lai
Email: order@dcchemicals.com

DC Chemicals Limited
China
Product Name: NAcM-OPT
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

2089293-61-6

2089293-61-6 structure

2089293-61-6 structure

Name: NAcM-OPT
Chemical Name: NAcM-OPT
CAS Number: 2089293-61-6
Molecular Formula: C₂₃H₂₉Cl₂N₃O
Molecular Weight: 434.40
Catalog: Signaling Pathways Metabolic Enzyme/Protease NEDD8-activating Enzyme
Create Date: 2019-03-03 11:55:02
Modify Date: 2025-08-24 21:14:03
NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction[1].

Name	NAcM-OPT

Description	NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> NEDD8-activating Enzyme
Target	DCN1[1]
In Vitro	NAcM-OPT (Compound 67) is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway[1].
References	[1]. Hammill JT, et al. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2694-2706.

Molecular Formula	C₂₃H₂₉Cl₂N₃O
Molecular Weight	434.40

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