NAcM-OPT

Modify Date: 2024-01-10 20:37:53

NAcM-OPT structure	Common Name	NAcM-OPT
	CAS Number	2089293-61-6	Molecular Weight	434.40
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₃H₂₉Cl₂N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of NAcM-OPT

NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction[1].

Name	NAcM-OPT

Description	NAcM-OPT is an orally bioavailable cullin neddylation 1 (DCN1) inhibitor, which potently inhibits the DCN1-UBE2M interaction[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> NEDD8-activating Enzyme
Target	DCN1[1]
In Vitro	NAcM-OPT (Compound 67) is orally bioavailable, well tolerated in mice, and currently used to study the effects of acute pharmacologic inhibition of the DCN1-UBE2M interaction on the NEDD8/CUL pathway[1].
References	[1]. Hammill JT, et al. Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem. 2018 Apr 12;61(7):2694-2706.

Molecular Formula	C₂₃H₂₉Cl₂N₃O
Molecular Weight	434.40

DC Chemicals Limited
China
Product Name: NAcM-OPT
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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