299919-79-2

299919-79-2 structure

Name: SARS-CoV-2-IN-33
Chemical Name: SARS-CoV-2-IN-33
CAS Number: 299919-79-2
Molecular Formula: C₃₀H₃₀N₄O₅
Molecular Weight: 526.58
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2022-11-22 01:21:48
Modify Date: 2024-01-03 16:26:09
SARS-CoV-2-IN-33 (compound 3m) is a COVID-19 inhibitor. SARS-CoV-2-IN-33 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-33 exhibits comparatively good binding affinity (-8.0 Kcal/mole) to COVID-19 main protease (Mpro) (PDB ID: 6LU7). SARS-CoV-2-IN-33 can be used in studies of cancer and COVID-19[1].

Name	SARS-CoV-2-IN-33

Description	SARS-CoV-2-IN-33 (compound 3m) is a COVID-19 inhibitor. SARS-CoV-2-IN-33 shows anti-proliferative activity against cancer cells. SARS-CoV-2-IN-33 exhibits comparatively good binding affinity (-8.0 Kcal/mole) to COVID-19 main protease (Mpro) (PDB ID: 6LU7). SARS-CoV-2-IN-33 can be used in studies of cancer and COVID-19[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	COVID-19[1].
In Vitro	SARS-CoV-2-IN-33 (0-40 µM) exhibits good antiproliferative activity in MCF-7, MDA-MB-231, HeLa and PC-3 cells[1]. Cell Proliferation Assay[1] Cell Line: MCF-7, MDA-MB-231, HeLa, PC-3, Ishikawa, HEK-293 Concentration: 0-40 µM Incubation Time: 48 h Result: Inhibited proliferation of MCF-7, MDA-MB-231, HeLa, PC-3, Ishikawa, HEK-293 cells with IC50 values of 5.45, 9.47, 22.86, 28.44, >40 and >40 μM, respectively.
References	[1]. Gupta A, et al. Visible Light-Promoted Green and Sustainable Approach for One-Pot Synthesis of 4, 4’-(Arylmethylene) bis (1H-pyrazol-5-ols), In Vitro Anticancer Activity, and Molecular Docking with Covid-19 Mpro. ACS Omega, 2022.

Molecular Formula	C₃₀H₃₀N₄O₅
Molecular Weight	526.58