302821-53-0

302821-53-0 structure

Name: SARS-CoV-2 3CLpro-IN-6
Chemical Name: SARS-CoV-2 3CLpro-IN-6
CAS Number: 302821-53-0
Molecular Formula: C₂₂H₁₅NO₇
Molecular Weight: 405.36
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2023-01-15 19:44:38
Modify Date: 2025-08-25 09:56:13
SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor of SARS-CoV-2 3CL protease. SARS-CoV-2 3CLpro-IN-6 has potent inhibitory activity for SARS-CoV-2 3CLpro with an IC50 value of 4.9 μM. SARS-CoV-2 3CLpro-IN-6 can be used for the research of coronavirus disease 2019 (COVID-19)[1].

Name	SARS-CoV-2 3CLpro-IN-6

Description	SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor of SARS-CoV-2 3CL protease. SARS-CoV-2 3CLpro-IN-6 has potent inhibitory activity for SARS-CoV-2 3CLpro with an IC50 value of 4.9 μM. SARS-CoV-2 3CLpro-IN-6 can be used for the research of coronavirus disease 2019 (COVID-19)[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 4.9 μM (SARS-CoV-2 3CLpro)[1]
In Vitro	SARS-CoV-2 3CLpro-IN-6 (Compound 13) (0-100 μM) has potent inhibitory activity for SARS-CoV-2 3CLpro with IC50 value of 4.9 μM[1]. SARS-CoV-2 3CLpro-IN-6 (5, 10 μM) has typical covalent inhibition behavior with time-dependent activity[1].
References	[1]. Liying Wang, et al. Discovery of novel SARS-CoV-2 3CL protease covalent inhibitors using deep learning-based screen. Eur J Med Chem. 2022 Dec 15;244:114803.

Molecular Formula	C₂₂H₁₅NO₇
Molecular Weight	405.36