SARS-CoV-2 3CLpro-IN-6

Modify Date: 2024-01-02 18:14:42

SARS-CoV-2 3CLpro-IN-6 Structure
SARS-CoV-2 3CLpro-IN-6 structure
Common Name SARS-CoV-2 3CLpro-IN-6
CAS Number 302821-53-0 Molecular Weight 405.36
Density N/A Boiling Point N/A
Molecular Formula C22H15NO7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of SARS-CoV-2 3CLpro-IN-6


SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor of SARS-CoV-2 3CL protease. SARS-CoV-2 3CLpro-IN-6 has potent inhibitory activity for SARS-CoV-2 3CLpro with an IC50 value of 4.9 μM. SARS-CoV-2 3CLpro-IN-6 can be used for the research of coronavirus disease 2019 (COVID-19)[1].

 Names

Name SARS-CoV-2 3CLpro-IN-6

 SARS-CoV-2 3CLpro-IN-6 Biological Activity

Description SARS-CoV-2 3CLpro-IN-6 is a reversible covalent inhibitor of SARS-CoV-2 3CL protease. SARS-CoV-2 3CLpro-IN-6 has potent inhibitory activity for SARS-CoV-2 3CLpro with an IC50 value of 4.9 μM. SARS-CoV-2 3CLpro-IN-6 can be used for the research of coronavirus disease 2019 (COVID-19)[1].
Related Catalog
Target

IC50: 4.9 μM (SARS-CoV-2 3CLpro)[1]

In Vitro SARS-CoV-2 3CLpro-IN-6 (Compound 13) (0-100 μM) has potent inhibitory activity for SARS-CoV-2 3CLpro with IC50 value of 4.9 μM[1]. SARS-CoV-2 3CLpro-IN-6 (5, 10 μM) has typical covalent inhibition behavior with time-dependent activity[1].
References

[1]. Liying Wang, et al. Discovery of novel SARS-CoV-2 3CL protease covalent inhibitors using deep learning-based screen. Eur J Med Chem. 2022 Dec 15;244:114803.  

 Chemical & Physical Properties

Molecular Formula C22H15NO7
Molecular Weight 405.36