2768834-48-4

2768834-48-4 structure

Name: SARS-CoV-2 Mpro-IN-6
Chemical Name: SARS-CoV-2 Mpro-IN-6
CAS Number: 2768834-48-4
Molecular Formula: C₁₈H₁₈Cl₃N₃O₂S
Molecular Weight: 446.78
Catalog: Signaling Pathways Anti-infection SARS-CoV
Create Date: 2023-03-10 07:31:38
Modify Date: 2025-08-22 17:44:07
SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 Mpro inhibitor with an IC50 of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3[1].

Name	SARS-CoV-2 Mpro-IN-6

Description	SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 Mpro inhibitor with an IC50 of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 0.18 μM (SARS-CoV-2 Mpro)[1]
In Vitro	SARS-CoV-2 Mpro-IN-6 (GD-9) 对 SARS-CoV-2 显示出良好的抗病毒效力 (ECsub>50 = 2.64 μM)。SARS-CoV-2 Mpro-IN-6 在 Vero E6 细胞中表现出一定的细胞毒性（CCsub>50 为 12.51 μM）[1]。
References	[1]. Shenghua Gao, et al. Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors. J Med Chem. 2022 Dec 22;65(24):16902-16917.

Molecular Formula	C₁₈H₁₈Cl₃N₃O₂S
Molecular Weight	446.78