SARS-CoV-2 Mpro-IN-6

Modify Date: 2025-08-22 17:44:07

SARS-CoV-2 Mpro-IN-6 structure	Common Name	SARS-CoV-2 Mpro-IN-6
	CAS Number	2768834-48-4	Molecular Weight	446.78
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₈Cl₃N₃O₂S	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of SARS-CoV-2 Mpro-IN-6

SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 Mpro inhibitor with an IC50 of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3[1].

Name	SARS-CoV-2 Mpro-IN-6

Description	SARS-CoV-2 Mpro-IN-6 is a covalent, irreversible and selective SARS-CoV-2 Mpro inhibitor with an IC50 of 0.18 μM. SARS-CoV-2 Mpro-IN-6 does not inhibit human cathepsins B, F, K, and L, and caspase 3[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> SARS-CoV
Target	IC50: 0.18 μM (SARS-CoV-2 Mpro)[1]
In Vitro	SARS-CoV-2 Mpro-IN-6 (GD-9) 对 SARS-CoV-2 显示出良好的抗病毒效力 (ECsub>50 = 2.64 μM)。SARS-CoV-2 Mpro-IN-6 在 Vero E6 细胞中表现出一定的细胞毒性（CCsub>50 为 12.51 μM）[1]。
References	[1]. Shenghua Gao, et al. Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors. J Med Chem. 2022 Dec 22;65(24):16902-16917.

Molecular Formula	C₁₈H₁₈Cl₃N₃O₂S
Molecular Weight	446.78

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