112192-04-8
112192-04-8 structure
- Name: Roxindole
- Chemical Name: roxindole
- CAS Number: 112192-04-8
- Molecular Formula: C23H26N2O
- Molecular Weight: 346.47
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2018-08-31 19:08:29
- Modify Date: 2025-08-25 10:57:58
-
Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3].
| Name | roxindole |
|---|---|
| Synonyms |
Roxindole
RoxindoleHCl Roxindole hydrochloride,3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-olhydrochloride ROXINDOLE HYDROCHLORIDE |
| Description | Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vivo | Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH- DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3]. Roxindole inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[4]. |
| References |
| Density | 1.173g/cm3 |
|---|---|
| Boiling Point | 575.7ºC at 760mmHg |
| Molecular Formula | C23H26N2O |
| Molecular Weight | 346.47 |
| Flash Point | 302ºC |
| Exact Mass | 346.20500 |
| PSA | 39.26000 |
| LogP | 4.92340 |
| Vapour Pressure | 7.46E-14mmHg at 25°C |
| Index of Refraction | 1.651 |
| HS Code | 2933990090 |
|---|
| Precursor 4 | |
|---|---|
| DownStream 0 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |