108050-82-4
108050-82-4 structure
- Name: Roxindole hydrochloride
- Chemical Name: Roxindole hydrochloride
- CAS Number: 108050-82-4
- Molecular Formula: C23H27ClN2O
- Molecular Weight: 382.92600
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2018-05-10 11:37:16
- Modify Date: 2024-01-09 17:56:08
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Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3].
| Name | Roxindole hydrochloride |
|---|---|
| Synonyms |
5-hydroxy-3-[4-(1,2,3,6-tetrahydro-4-phenyl-1-pyridyl)butyl]indole hydrochloride
3-[4-(4-Phenyl-3,6-dihydro-2H-pyridin-1-yl)-butyl]-1H-indol-5-ol hydrochloride |
| Description | Roxindole hydrochloride (EMD 38362), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vivo | Roxindole hydrochloride inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[1]. Roxindole hydrochloride (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH-DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3]. |
| References |
| Molecular Formula | C23H27ClN2O |
|---|---|
| Molecular Weight | 382.92600 |
| Exact Mass | 382.18100 |
| PSA | 39.26000 |
| LogP | 5.72540 |