Roxindole

Modify Date: 2024-01-11 14:54:14

Roxindole Structure
Roxindole structure
 Common Name Roxindole
CAS Number 112192-04-8 Molecular Weight 346.47
Density 1.173g/cm3 Boiling Point 575.7ºC at 760mmHg
Molecular Formula C23H26N2O Melting Point N/A
MSDS N/A Flash Point 302ºC

 Use of Roxindole


Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3].

 Names

Name roxindole
Synonym More Synonyms

 Roxindole Biological Activity

Description Roxindole (EMD 49980), an indot-alkyl-pipenidine, is a potent agonist at dopamine autoreceptors, with an affinity for the D2-like subtype in the low nanomolar range. Roxindole can be used for the research of positive and negative schizophrenic symptoms. Roxindole is a 5-HT1A agonist and 5-HT uptake inhibitor with high affinity for 5-HT1A (IC50=0.9 nM). Antipsychotic and antidepressant activities[1][2][3].
Related Catalog
In Vivo Roxindole (EMD 49980) (1, 3, 10 mg/kg; s.c) inhibits both effects of 8-OH- DPAT (flat body and forepaw treading) in normal rats (male Wistar 200-350g)[3]. Roxindole inhibits apomorphine-induced climbing in mice and stereotyped behavior in rats with ED50s of 1.4 mg/kg s.c. and 0.65 mg/kg s.c., respectively, and inhibits conditioned avoidance response in rats (ED50=1.5 mg/kg s.c.)[4].
References

[1]. Bartoszyk GD, Harting J, Minck KO. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276(1):41-48.

[2]. Wetzel H, et al. Roxindole, a dopamine autoreceptor agonist, in the treatment of positive and negative schizophrenic symptoms. Am J Psychiatry. 1994;151(10):1499-1502.

[3]. Maj J, et al. Roxindole, a dopamine autoreceptor agonist with a potential antidepressant activity. II. Effects on the 5-hydroxytryptamine system. Pharmacopsychiatry. 1997;30(2):55-61.

[4]. Bartoszyk GD, et al. Roxindole: psychopharmacological profile of a dopamine D2 autoreceptor agonist. J Pharmacol Exp Ther. 1996;276(1):41-48.

 Chemical & Physical Properties

Density 1.173g/cm3
Boiling Point 575.7ºC at 760mmHg
Molecular Formula C23H26N2O
Molecular Weight 346.47
Flash Point 302ºC
Exact Mass 346.20500
PSA 39.26000
LogP 4.92340
Vapour Pressure 7.46E-14mmHg at 25°C
Index of Refraction 1.651

 Safety Information

HS Code 2933990090

 Customs

HS Code 2933990090
Summary 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

Roxindole
RoxindoleHCl
Roxindole hydrochloride,3-[4-(3,6-Dihydro-4-phenyl-1(2H)-pyridinyl)butyl]-1H-indol-5-olhydrochloride
ROXINDOLE HYDROCHLORIDE
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Related Compounds: More...
ROXINDOLE MESYLATE
119742-13-1
Roxindole hydrochloride
502486-89-7
Roxindole hydrochloride
108050-82-4
Chemsrc provides Roxindole(CAS#:112192-04-8) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of Roxindole are included as well.>> amp version: Roxindole

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